Flying under the radar: the new wave of BCR-ABL inhibitors (Q36939898)

17 August 2017

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title

Flying under the radar: the new wave of BCR-ABL inhibitors (English)

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17 August 2017

Hagop Kantarjian

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17 August 2017

Jorge Cortes

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17 August 2017

author name string

Alfonso Quintás-Cardama

series ordinal

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17 August 2017

publication date

1 October 2007

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Nature Reviews Drug Discovery

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

834-848

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A cell-based screening strategy that predicts mutations in oncogenic tyrosine kinases: implications for clinical resistance in targeted cancer treatment

17 August 2017

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31 March 2020

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Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia

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Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

31 March 2020

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A Src-like inactive conformation in the abl tyrosine kinase domain

31 March 2020

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

31 March 2020

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In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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A small molecule-kinase interaction map for clinical kinase inhibitors

31 March 2020

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31 March 2020

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AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

31 March 2020

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A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia

31 March 2020

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31 March 2020

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31 March 2020

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A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

31 March 2020

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Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

31 March 2020

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31 March 2020

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31 March 2020

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A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

31 March 2020

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EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

31 March 2020

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

31 March 2020

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The protein tyrosine kinase family of the human genome

31 March 2020

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The protein kinase complement of the human genome

31 March 2020

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Rational design of inhibitors that bind to inactive kinase conformations

31 March 2020

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

31 March 2020

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Substrate competitive inhibitors of IGF-1 receptor kinase

31 March 2020

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Mitotic kinases as regulators of cell division and its checkpoints

31 March 2020

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Structure-function relationships in Src family and related protein tyrosine kinases

31 March 2020

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Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2324

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Dimensions Publication ID

17 August 2017

1038262700

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