A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux (Q36928959)

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scientific article published on 03 May 2013

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English	A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux	scientific article published on 03 May 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

endoplasmic reticulum

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apoptotic process

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based on heuristic

inferred from title

Mridusmita Saikia

object named as

Mridusmita Saikia

3

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Marek Tchórzewski

object named as

Marek Tchórzewski

11

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Ovidio Bussolati

object named as

Ovidio Bussolati

8

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Dawid Krokowski

1

object named as

Dawid Krokowski

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17 August 2017

author name string

Jaeseok Han

2

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17 August 2017

Mithu Majumder

4

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17 August 2017

Celvie L Yuan

5

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17 August 2017

Bo-Jhih Guan

6

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17 August 2017

Elena Bevilacqua

7

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17 August 2017

Stefan Bröer

9

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17 August 2017

Peter Arvan

10

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17 August 2017

Martin D Snider

12

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17 August 2017

Michelle Puchowicz

13

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17 August 2017

Colleen M Croniger

14

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17 August 2017

Scot R Kimball

15

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17 August 2017

Tao Pan

16

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17 August 2017

Antonis E Koromilas

17

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17 August 2017

Randal J Kaufman

18

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17 August 2017

Maria Hatzoglou

19

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17 August 2017

language of work or name

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publication date

3 May 2013

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17 August 2017

Journal of Biological Chemistry

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17 August 2017

288

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17 August 2017

24

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17 August 2017

17202-17213

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Fluorine-18 labeled amino acids for oncologic imaging with positron emission tomography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Amino acids and mTORC1: from lysosomes to disease

1 reference

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29 September 2017

A unifying model for mTORC1-mediated regulation of mRNA translation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Endoplasmic reticulum stress and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Leucine signaling in the pathogenesis of type 2 diabetes and obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

1 reference

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29 September 2017

Mechanisms for insulin resistance: common threads and missing links

1 reference

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29 September 2017

An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production

1 reference

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29 September 2017

A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Metabolite profiles and the risk of developing diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

1 reference

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29 September 2017

The binary switch that controls the life and death decisions of ER stressed β cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

1 reference

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29 September 2017

Regulation of the unfolded protein response by eif2Bdelta isoforms.

1 reference

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29 September 2017

Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis

1 reference

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29 September 2017

Molecular symbiosis of CHOP and C/EBP beta isoform LIP contributes to endoplasmic reticulum stress-induced apoptosis

1 reference

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29 September 2017

eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress

1 reference

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29 September 2017

ATF4-dependent transcription mediates signaling of amino acid limitation

1 reference

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29 September 2017

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Atf4 regulates obesity, glucose homeostasis, and energy expenditure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Bidirectional transport of amino acids regulates mTOR and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation

1 reference

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29 September 2017

Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells

1 reference

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Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

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29 September 2017

Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake.

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Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle.

1 reference

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29 September 2017

Amino acid transport across mammalian intestinal and renal epithelia

1 reference

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29 September 2017

Proinsulin maturation, misfolding, and proteotoxicity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

The mTOR pathway in the control of protein synthesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682525

29 September 2017

The role of the neutral amino acid transporter SNAT2 in cell volume regulation.

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29 September 2017

Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.

1 reference

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29 September 2017

L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier

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29 September 2017

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

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29 September 2017

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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Regulation of cationic amino acid transport: the story of the CAT-1 transporter.

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29 September 2017

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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29 September 2017

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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29 September 2017

Activation of system L heterodimeric amino acid exchangers by intracellular substrates

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29 September 2017

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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29 September 2017

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

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29 September 2017

Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases

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Beta-cell failure, stress, and type 2 diabetes

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Towards PET imaging of intact pancreatic beta cell mass: a transgenic strategy

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4 September 2018

A protocol for islet isolation from mouse pancreas

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Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha

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https://pubmed.ncbi.nlm.nih.gov/23645676

12 December 2020

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Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23645676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.466920

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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