NF-kappaB and the intestine: friend or foe? (Q36925725)

17 August 2017

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title

NF-kappaB and the intestine: friend or foe? (English)

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17 August 2017

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Thomas Karrasch

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17 August 2017

Christian Jobin

series ordinal

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17 August 2017

publication date

1 January 2008

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Inflammatory Bowel Diseases

17 August 2017

published in

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

114-124

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

17 August 2017

cites work

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

21 January 2018

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The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression

21 January 2018

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Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

21 January 2018

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NF-kappaB and the immune response

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NF-kappa B activation as a pathological mechanism of septic shock and inflammation

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The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

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Introduction to NF-kappaB: players, pathways, perspectives

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

21 January 2018

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The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

21 January 2018

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Regulation and function of IKK and IKK-related kinases

21 January 2018

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TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

21 January 2018

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

21 January 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

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Back to the future with ubiquitin

21 January 2018

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Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

21 January 2018

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Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis

21 January 2018

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Cytokine therapy for Crohn's disease: advances in translational research

21 January 2018

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Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

21 January 2018

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Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour?

21 January 2018

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TLRs in the Gut I. The role of TLRs/Nods in intestinal development and homeostasis.

21 January 2018

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Intestinal epithelial toll-like receptors: to protect. And serve?

21 January 2018

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Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease

21 January 2018

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Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression

21 January 2018

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In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain

21 January 2018

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TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells

21 January 2018

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Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut.

21 January 2018

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Toll-like receptors; their physiological role and signal transduction system

21 January 2018

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Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells

21 January 2018

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Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells

21 January 2018

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Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily

21 January 2018

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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

21 January 2018

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IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis.

21 January 2018

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Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation

21 January 2018

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IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

21 January 2018

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

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General nature of the STAT3-activated anti-inflammatory response.

21 January 2018

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STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells

21 January 2018

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The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.

21 January 2018

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Gliotoxin, an inhibitor of nuclear factor-kappa B, attenuates peptidoglycan-polysaccharide-induced colitis in rats

21 January 2018

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In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats

21 January 2018

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Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice

21 January 2018

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Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis

21 January 2018

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In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway

21 January 2018

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Theaflavin-3,3'-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-kappaB in macrophages

21 January 2018

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Protection from experimental colitis by theaflavin-3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation

21 January 2018

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The flavonoid luteolin prevents lipopolysaccharide-induced NF-kappaB signalling and gene expression by blocking IkappaB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells

21 January 2018

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Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.

21 January 2018

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In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model

21 January 2018

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Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase

21 January 2018

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Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages

21 January 2018

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The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules

21 January 2018

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Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.

21 January 2018

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Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains

21 January 2018

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

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Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

21 January 2018

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

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CARD15/NOD2 is required for Peyer's patches homeostasis in mice

21 January 2018

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 January 2018

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Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.

21 January 2018

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Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury

21 January 2018

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Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes

21 January 2018

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Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta

21 January 2018

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IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

21 January 2018

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The risk of colorectal cancer in ulcerative colitis: a meta-analysis

21 January 2018

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Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota

21 January 2018

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Nuclear factor-kappaB in cancer development and progression

21 January 2018

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NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

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Promotion of colorectal neoplasia in experimental murine ulcerative colitis

21 January 2018

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A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate

21 January 2018

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

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Ubiquitin protein modification and signal transduction: implications for inflammatory bowel diseases

21 January 2018

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Mechanism and function of deubiquitinating enzymes

21 January 2018

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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

21 January 2018

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

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Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

21 January 2018

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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

21 January 2018

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Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

21 January 2018

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Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium

21 January 2018

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Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.

21 January 2018

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CpG island methylation in gastroenterologic neoplasia: a maturing field.

21 January 2018

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Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice

21 January 2018

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Inhibitors of NF-kappaB signaling: 785 and counting

21 January 2018

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Activation of nuclear factor kappa B in Crohn's disease

21 January 2018

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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

21 January 2018

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Epithelial NEMO links innate immunity to chronic intestinal inflammation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IBD.20243

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17 August 2017

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