Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist. (Q36913461)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

1 reference

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2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Maureen J Charron

1 reference

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2 April 2020

Fabrizio Thorel

1 reference

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2 April 2020

Julie S Moyers

series ordinal

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2 April 2020

Patricia M Vuguin

series ordinal

1 reference

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2 April 2020

Alvin C Powers

series ordinal

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2 April 2020

language of work or name

English

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publication date

19 April 2016

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2 April 2020

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2 April 2020

volume

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describes a project that uses

2 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4871705/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.

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Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models

29 September 2017

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Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

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Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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27 June 2018

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Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes.

27 June 2018

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Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

4 September 2018

1 reference

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Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor

4 September 2018

1 reference

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Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871705

A novel high-affinity peptide antagonist to the insulin receptor

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871705

Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871705

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4871705

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

4 September 2018

1 reference

12 December 2020

Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice

1 reference

12 December 2020

Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

Hyperglucagonemia and Blood Glucose Regulation in Normal, Obese and Diabetic Subjects

1 reference

12 December 2020

Hyperglycemia of Diabetic Rats Decreased by a Glucagon Receptor Antagonist

1 reference

12 December 2020

Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats

1 reference

12 December 2020

Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced beta cell death in inbred mice

1 reference

12 December 2020

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.13828

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

27092792

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27092792%20AND%20SRC:MED&resulttype=core&format=json