ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model (Q36910394)

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scientific article published on 18 May 2016

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English	ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model	scientific article published on 18 May 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model (English)

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Europe PubMed Central

PMC publication ID

17 August 2017

Alzheimer's disease

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Christopher S. Chen

4

object named as

Christopher Chen

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Europe PubMed Central

17 August 2017

PMC publication ID

author name string

Elizabeth S Chan

1

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Europe PubMed Central

PMC publication ID

17 August 2017

Mahesh Shivarama Shetty

2

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17 August 2017

Sreedharan Sajikumar

3

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17 August 2017

Tuck Wah Soong

5

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17 August 2017

Boon-Seng Wong

6

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17 August 2017

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publication date

18 May 2016

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17 August 2017

Scientific Reports

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17 August 2017

6

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Europe PubMed Central

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17 August 2017

26119

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Europe PubMed Central

PMC publication ID

17 August 2017

copyright license

Creative Commons Attribution 4.0 International

18 May 2016

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April 2022 Public Data File from Crossref

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APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults

1 reference

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1 reference

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Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice

1 reference

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APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice.

1 reference

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Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

1 reference

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APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease.

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PI3K-PKB/Akt pathway

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Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

1 reference

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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

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Neuropathological alterations in Alzheimer disease

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Introducing Human APOE into Aβ Transgenic Mouse Models

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C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice

1 reference

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

1 reference

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ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

1 reference

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Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus

1 reference

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APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease

1 reference

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AKT/PKB signaling: navigating downstream

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Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1.

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Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease

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Insulin and neurodegenerative disease: shared and specific mechanisms

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Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory

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AMPA receptor trafficking and synaptic plasticity

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Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27189808

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/SREP26119

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Europe PubMed Central

PMC publication ID

17 August 2017

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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