ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation (Q36918817)

17 August 2017

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation (English)

1 reference

17 August 2017

Michael Karin

1 reference

17 August 2017

Garth Powis

1 reference

17 August 2017

Petrus R de Jong

1 reference

17 August 2017

Koji Taniguchi

1 reference

17 August 2017

Alexandra R Harris

1 reference

17 August 2017

Samuel Bertin

1 reference

17 August 2017

Naoki Takahashi

1 reference

17 August 2017

Jen Duong

1 reference

17 August 2017

Alejandro D Campos

1 reference

17 August 2017

Maripat Corr

1 reference

17 August 2017

Eyal Raz

1 reference

17 August 2017

language of work or name

English

0 references

publication date

17 May 2016

1 reference

17 August 2017

Nature Communications

1 reference

17 August 2017

1 reference

17 August 2017

11551

1 reference

Creative Commons Attribution 4.0 International

17 August 2017

start time

17 May 2016

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

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The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4⁺ T cells

29 September 2017

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TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

29 September 2017

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Polarizing intestinal epithelial cells electrically through Ror2

29 September 2017

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A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF.

29 September 2017

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Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

29 September 2017

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Tumor adaptation and resistance to RAF inhibitors

29 September 2017

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Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions

29 September 2017

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The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs).

29 September 2017

1 reference

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Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice

29 September 2017

1 reference

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ERK5: structure, regulation and function.

29 September 2017

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Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

29 September 2017

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Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

29 September 2017

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Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.

29 September 2017

1 reference

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

29 September 2017

1 reference

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Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand

29 September 2017

1 reference

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Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia

29 September 2017

1 reference

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Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells

29 September 2017

1 reference

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Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

29 September 2017

1 reference

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

29 September 2017

1 reference

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Dicer1 functions as a haploinsufficient tumor suppressor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Erk1/2 MAP kinases are required for epidermal G2/M progression

29 September 2017

1 reference

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

29 September 2017

1 reference

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ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos

29 September 2017

1 reference

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Dual-specificity phosphatases: critical regulators with diverse cellular targets

29 September 2017

1 reference

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ERBBs in the gastrointestinal tract: recent progress and new perspectives

29 September 2017

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Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer

29 September 2017

1 reference

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Stem cells, self-renewal, and differentiation in the intestinal epithelium

29 September 2017

1 reference

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Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels

29 September 2017

1 reference

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HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway

29 September 2017

1 reference

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ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

MAPK signalling: ERK5 versus ERK1/2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

MAPK signal specificity: the right place at the right time

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Cell migration: integrating signals from front to back

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Paneth and goblet cell renewal in mouse duodenal crypts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Retroviral gene expression control in primary organoid cultures

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

ERK regulates strain-induced migration and proliferation from different subcellular locations

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

The role of erk1 and erk2 in multiple stages of T cell development

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Regulation and role of brush border-associated ERK1/2 in intestinal epithelial cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Activation of cyclin D1 expression by the ERK5 cascade

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4873670

Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27187615

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27187615

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SnapShot: The Intestinal Crypt

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27187615

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS11551

1 reference

17 August 2017

0 references

1 reference

17 August 2017

PubMed publication ID

27187615

1 reference