A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability (Q36917040)

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scientific article published on 10 September 2012

Language	Label	Description	Also known as
English	A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability	scientific article published on 10 September 2012

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

0 references

author name string

Ram P Naikawadi

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Ni Cheng

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Stephen M Vogel

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Feng Qian

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dianqing Wu

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Asrar B Malik

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Richard D Ye

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

10 September 2012

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Circulation Research

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

111

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1517-1527

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

1 reference

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The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.

1 reference

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The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species

1 reference

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Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

1 reference

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GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability

1 reference

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Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability

1 reference

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P-Rex1 - a multidomain protein that regulates neurite differentiation

1 reference

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p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation

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Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation

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VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

1 reference

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Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function

1 reference

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TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia

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29 September 2017

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

1 reference

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29 September 2017

P-Rex1 regulates neutrophil function

1 reference

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29 September 2017

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration

1 reference

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

1 reference

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29 September 2017

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

1 reference

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

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VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam

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TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes

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29 September 2017

Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo

1 reference

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Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

1 reference

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29 September 2017

Regulation and function of the Rho subfamily of small GTPases

1 reference

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Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins

1 reference

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Pathophysiology of the adult respiratory distress syndrome. What have we learned from human studies?

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Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

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Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

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Adhesive proteins at endothelial cell-to-cell junctions and leukocyte extravasation

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P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

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HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway.

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1 reference

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1 reference

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Plasma levels of tumor necrosis factor in the adult respiratory distress syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of phagocyte NADPH oxidase components in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VE-cadherin antibody accelerates neutrophil recruitment in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked

1 reference

https://pubmed.ncbi.nlm.nih.gov/22965143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.112.273078

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

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