Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection (Q36914625)

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scientific article published on 3 January 2008

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English	Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection	scientific article published on 3 January 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

title

Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection (English)

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

author name string

Nadeem Wajih

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1

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

John Owen

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2

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

Reidar Wallin

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3

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

publication date

3 January 2008

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

published in

Thrombosis Research

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

volume

122

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

issue

3

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

page(s)

405-410

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Europe PubMed Central

PMC publication ID

2556075

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17 August 2017

cites work

Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Management of sepsis

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

siRNA silencing of calumenin enhances functional factor IX production

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Mechanism of action of recombinant activated factor VII: an update

1 reference

stated in

PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

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29 September 2017

Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

New high-technology products for the treatment of haemophilia

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Warfarin and the vitamin K-dependent gamma-carboxylation system

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

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29 September 2017

The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Vitamin K 2,3-epoxide reductase and the vitamin K-dependent gamma-carboxylation system

1 reference

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PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

The CREC family, a novel family of multiple EF-hand, low-affinity Ca(2+)-binding proteins localised to the secretory pathway of mammalian cells

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin

1 reference

stated in

PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

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29 September 2017

Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

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29 September 2017

Molecular and cellular biology of blood coagulation

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2556075

retrieved

29 September 2017

Identifiers

DOI

10.1016/J.THROMRES.2007.11.002

1 reference

stated in

Europe PubMed Central

PMC publication ID

2556075

retrieved

17 August 2017

PMC publication ID

2556075

1 reference

stated in

Europe PubMed Central

PMC publication ID

2556075

retrieved

17 August 2017

PubMed publication ID

18177690

1 reference

stated in

Europe PubMed Central

PMC publication ID

2556075

retrieved

17 August 2017

ResearchGate publication ID

5672009

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