The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. (Q36909451)

17 August 2017

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. (English)

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17 August 2017

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8 June 2020

D Zamolodchikov

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8 June 2020

T Renné

series ordinal

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8 June 2020

publication date

28 November 2015

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Journal of Thrombosis and Haemostasis

17 August 2017

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8 June 2020

volume

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8 June 2020

issue

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8 June 2020

page(s)

995-1007

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Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1

8 June 2020

cites work

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Activation of the factor XII-driven contact system in Alzheimer's disease patient and mouse model plasma

29 September 2017

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The overlap between vascular disease and Alzheimer's disease--lessons from pathology

29 September 2017

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Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts.

29 September 2017

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A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.

29 September 2017

1 reference

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ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function

29 September 2017

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Increased number of microinfarcts in Alzheimer disease at 7-T MR imaging

29 September 2017

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Ongoing contact activation in patients with hereditary angioedema

29 September 2017

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Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain

29 September 2017

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In vivo roles of factor XII.

29 September 2017

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Plasma amyloid-β levels and prognosis in incident dementia cases of the 3-City Study

29 September 2017

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Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD.

29 September 2017

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Fibrinogen and altered hemostasis in Alzheimer's disease

29 September 2017

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Alzheimer's disease and the amyloid β-protein

29 September 2017

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Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease

29 September 2017

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Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin.

29 September 2017

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Cerebral microinfarcts: a systematic review of neuropathological studies

29 September 2017

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Blood-based biomarkers for Alzheimer's disease: plasma Aβ40 and Aβ42, and genetic variants

29 September 2017

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The pathologic cascade of cerebrovascular lesions in SHRSP: is erythrocyte accumulation an early phase?

29 September 2017

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Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets

29 September 2017

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Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries.

29 September 2017

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Ceruloplasmin/Transferrin ratio changes in Alzheimer's disease

29 September 2017

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Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?

29 September 2017

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Preparing Synthetic Aβ in Different Aggregation States

29 September 2017

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Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

29 September 2017

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Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease

29 September 2017

1 reference

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Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation

29 September 2017

1 reference

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Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.

29 September 2017

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Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo

29 September 2017

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The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability

29 September 2017

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Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C

29 September 2017

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The role of cerebral ischemia in Alzheimer's disease

29 September 2017

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The amyloid precursor protein of Alzheimer's disease and the Abeta peptide.

29 September 2017

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The Clinical Dementia Rating (CDR): current version and scoring rules

29 September 2017

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Hageman factor and its binding sites are present in senile plaques of Alzheimer's disease

29 September 2017

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The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

29 September 2017

1 reference

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Senile-presenile dementia: follow-up data on an effective psychotherapy-anticoagulant regimen

29 September 2017

1 reference

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Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

29 September 2017

1 reference

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Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study

27 June 2018

1 reference

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Anticoagulant Therapy for Senile Dementia*

27 June 2018

1 reference

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Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Alzheimer disease and risk of stroke: a population-based cohort study.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Plasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Thrombin mediates severe neurovascular injury during ischemia

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease.

4 September 2018

1 reference

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Stroke and the risk of Alzheimer disease

4 September 2018

1 reference

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Silent brain infarcts and the risk of dementia and cognitive decline

4 September 2018

1 reference

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Activation of complement and contact system in Alzheimer's disease.

4 September 2018

1 reference

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Increased fibrin monomer plasma concentration in stable coronary artery disease in patients without oral anticoagulation

4 September 2018

1 reference

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The region 1-11 of Alzheimer amyloid-beta is critical for activation of contact-kinin system.

4 September 2018

1 reference

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A murine model of factor XI deficiency.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

The value of quantitative fibrin monomer determination in the early diagnosis of postoperative deep vein thrombosis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984)

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4870142

Clearance of human factor XIa-inhibitor complexes in rats

4 September 2018

1 reference

12 December 2020

Zinc-dependent activation of the plasma kinin-forming cascade by aggregated beta amyloid protein

1 reference

12 December 2020

Activation of clotting factor XI without detectable contact activation in experimental human endotoxemia

1 reference

12 December 2020

Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor

1 reference

12 December 2020

Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen

1 reference

12 December 2020

Prothrombin fragments F1+2, thrombin-antithrombin III complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis

1 reference

12 December 2020

Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

1 reference

12 December 2020

Activated factor XII type A predicts long-term mortality in patients admitted with chest pain

1 reference

12 December 2020

Development of a calibrated automated thrombography based thrombin generation test in mouse plasma

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12 December 2020

Identifiers

DOI

10.1111/JTH.13209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26613657%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26613657%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

26613657

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26613657%20AND%20SRC:MED&resulttype=core&format=json