Hedgehog signaling in mammary gland development and breast cancer (Q36876335)

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scientific article published on September 2007

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English	Hedgehog signaling in mammary gland development and breast cancer	scientific article published on September 2007

Statements

instance of

scholarly article

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

review article

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stated in

Europe PubMed Central

title

Hedgehog signaling in mammary gland development and breast cancer (English)

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

main subject

breast cancer

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based on heuristic

inferred from title

author name string

Sarah Hatsell

series ordinal

1

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

Andra R Frost

series ordinal

2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

publication date

1 September 2007

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

published in

Journal of Mammary Gland Biology and Neoplasia

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

volume

12

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

issue

2-3

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stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

page(s)

163-173

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Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

cites work

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Essential role for Sonic hedgehog during hair follicle morphogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebrate Smoothened functions at the primary cilium

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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inferred from PubMed ID database lookup

Differential requirements for shh in mammary tissue and hair follicle morphogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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Identification of pancreatic cancer stem cells

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Emerging roles for hedgehog-patched-Gli signal transduction in reproduction

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

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https://pubmed.ncbi.nlm.nih.gov/17623270

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the mammary line in mouse by Wnt10b expression.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Ultrastructural studies of the female breast: I. 9 + 0 cilia in myoepithelial cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cilia and Hedgehog responsiveness in the mouse

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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Basal cell nevus syndrome

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Gli2 transcription factor is required for normal mouse mammary gland development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hedgehog signaling network, mammary stem cells, and breast cancer: connections and controversies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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based on heuristic

inferred from PubMed ID database lookup

Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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based on heuristic

inferred from PubMed ID database lookup

Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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The consensus coding sequences of human breast and colorectal cancers

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medulloblastoma growth inhibition by hedgehog pathway blockade

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammary stem cells, self-renewal pathways, and carcinogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Interpreting epithelial cancer biology in the context of stem cells: tumor properties and therapeutic implications.

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Nearly all cells in vertebrates and many cells in invertebrates contain primary cilia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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The hedgehog signaling network

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Hedgehog signaling is activated in subsets of esophageal cancers

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Activation of the hedgehog pathway in advanced prostate cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the hedgehog pathway in human hepatocellular carcinomas.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse prostate cancer model induced by Hedgehog overexpression

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12 December 2020

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An incredible decade for the primary cilium: a look at a once-forgotten organelle

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

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A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk.

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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The world according to hedgehog

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

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Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The primary cilium in cell signaling and cancer

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signalling: how to get from Smo to Ci and Gli.

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sonic hedgehog signaling is essential for hair development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shh expression is required for embryonic hair follicle but not mammary gland development

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basal cell carcinomas in mice overexpressing sonic hedgehog

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia

1 reference

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https://pubmed.ncbi.nlm.nih.gov/17623270

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling promotes prostate xenograft tumor growth

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling in mouse mammary gland development and neoplasia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histologic and ultrastructural features of adenoid cystic carcinoma of the breast

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the hedgehog pathway in a subset of lung cancers

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medulloblastoma: a problem of developmental biology

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hedgehog signaling in human hepatocellular carcinoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in SUFU predispose to medulloblastoma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17623270

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S10911-007-9048-2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

PubMed publication ID

17623270

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17623270

retrieved

16 August 2017

 

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