The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches? (Q36836686)

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31 December 2019

review article

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title

The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches? (English)

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31 December 2019

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31 December 2019

Alexandre de la Taille

object named as

Alexandre de la Taille

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31 December 2019

Bernard Paule

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31 December 2019

Laurence Kheuang

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31 December 2019

Pascale Soyeux

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31 December 2019

Francis Vacherot

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31 December 2019

publication date

31 May 2007

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31 December 2019

published in

World Journal of Urology

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31 December 2019

volume

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issue

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31 December 2019

page(s)

477-489

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Interleukin-6 is an autocrine growth factor in human prostate cancer.

31 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00345-007-0175-6

Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00345-007-0175-6

Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00345-007-0175-6

NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00345-007-0175-6

Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00345-007-0175-6

Akt in prostate cancer: possible role in androgen-independence

21 January 2018

1 reference

12 December 2020

NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.

1 reference

12 December 2020

EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells

1 reference

12 December 2020

Stat3 activation in prostatic carcinomas.

1 reference

12 December 2020

The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells

1 reference

12 December 2020

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

1 reference

12 December 2020

Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways

1 reference

12 December 2020

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor

1 reference

12 December 2020

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

1 reference

12 December 2020

Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis

1 reference

12 December 2020

Control of apoptosis by Rel/NF-kappaB transcription factors

1 reference

12 December 2020

Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation

1 reference

12 December 2020

Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia.

1 reference

12 December 2020

Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer

1 reference

12 December 2020

Thalidomide and its analogues as cyclooxygenase inhibitors

1 reference

12 December 2020

Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells

1 reference

12 December 2020

Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway .

1 reference

12 December 2020

STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells .

1 reference

12 December 2020

Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene.

1 reference

12 December 2020

Role of NF-κB in p53-mediated programmed cell death

1 reference

12 December 2020

Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway

1 reference

12 December 2020

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

1 reference

12 December 2020

Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma

1 reference

12 December 2020

Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells

1 reference

12 December 2020

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells

1 reference

12 December 2020

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

1 reference

12 December 2020

Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton

1 reference

12 December 2020

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

1 reference

12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

1 reference

12 December 2020

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

1 reference

12 December 2020

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro

1 reference

12 December 2020

Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo

1 reference

12 December 2020

Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone

1 reference

12 December 2020

The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer

1 reference

12 December 2020

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

12 December 2020

APPL suppresses androgen receptor transactivation via potentiating Akt activity

1 reference

12 December 2020

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

1 reference

12 December 2020

Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence

1 reference

12 December 2020

Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide-mediated cytotoxicity of human prostate carcinoma cell lines.

1 reference

12 December 2020

Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells

1 reference

12 December 2020

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

1 reference

12 December 2020

Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer

1 reference

12 December 2020

Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation

1 reference

12 December 2020

p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6

1 reference

12 December 2020

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

1 reference

12 December 2020

Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

1 reference

12 December 2020

The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity

1 reference

12 December 2020

Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest

1 reference

12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

1 reference

12 December 2020

Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

1 reference

12 December 2020

Androgen deprivation increases p300 expression in prostate cancer cells

1 reference

12 December 2020

Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells

1 reference

12 December 2020

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

1 reference

12 December 2020

Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma

1 reference

12 December 2020

NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?

1 reference

12 December 2020

Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers.

1 reference

12 December 2020

Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways

1 reference

12 December 2020

Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points.

1 reference

12 December 2020

Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

1 reference

12 December 2020

Thalidomid: current role in the treatment of non-plasma cell malignancies.

1 reference

12 December 2020

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

1 reference

12 December 2020

Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells

1 reference

12 December 2020

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

1 reference

12 December 2020

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

1 reference

12 December 2020

STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

1 reference

12 December 2020

Androgen receptor signaling: mechanism of interleukin-6 inhibition.

1 reference

12 December 2020

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

1 reference

12 December 2020

Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter

1 reference

12 December 2020

NF??B: A Pivotal Transcription Factor in Prostate Cancer Metastasis to Bone

1 reference

12 December 2020

Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells

1 reference

12 December 2020

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

1 reference

12 December 2020

Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

1 reference

12 December 2020

Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells

1 reference

12 December 2020

Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells

1 reference

12 December 2020

Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells

1 reference

12 December 2020

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

1 reference

12 December 2020

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1 reference

12 December 2020

Interleukin-6 and prostate cancer progression

1 reference

12 December 2020

Cytokine traps: multi-component, high-affinity blockers of cytokine action

1 reference

12 December 2020

Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines

1 reference

12 December 2020

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

1 reference

12 December 2020

Endogenous inhibitors of nuclear factor-kB, an opportunity for cancer control

1 reference

12 December 2020

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

12 December 2020

NF-kappaB in cancer: from innocent bystander to major culprit

1 reference

12 December 2020

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

1 reference

12 December 2020

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

12 December 2020

Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells

1 reference

12 December 2020

C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells

1 reference

12 December 2020

Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells

1 reference

12 December 2020

Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.

1 reference

12 December 2020

Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype

1 reference

12 December 2020

PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism

1 reference

12 December 2020

Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer

1 reference

12 December 2020

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells

1 reference

12 December 2020

Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer

1 reference

12 December 2020

Antiangiogenic activity of N-substituted and tetrafluorinated thalidomide analogues

1 reference

12 December 2020

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

1 reference

12 December 2020

Constitutive activation of nuclear factor kappaB in hepatocellular carcinoma

1 reference

12 December 2020

p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6

1 reference

12 December 2020

Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells

1 reference

12 December 2020

Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model

1 reference

12 December 2020

Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen

1 reference

12 December 2020

Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells.

1 reference

12 December 2020

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

1 reference

12 December 2020

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

1 reference

12 December 2020

Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression.

1 reference

12 December 2020

NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer

1 reference

12 December 2020

10.1007/S00345-007-0175-6

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