Insulin resistance: metabolic mechanisms and consequences in the heart. (Q36821424)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895668%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Insulin resistance: metabolic mechanisms and consequences in the heart (English)

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11 February 2020

1 reference

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11 February 2020

Ravichandran Ramasamy

series ordinal

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11 February 2020

Karen M O'Shea

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11 February 2020

language of work or name

English

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publication date

1 September 2012

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Arteriosclerosis, Thrombosis, and Vascular Biology

11 February 2020

published in

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11 February 2020

volume

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11 February 2020

issue

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11 February 2020

page(s)

2068-2076

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Lipid metabolism and toxicity in the heart

11 February 2020

cites work

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The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach.

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Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials

29 September 2017

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AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

29 September 2017

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New insights into insulin resistance in the diabetic heart

29 September 2017

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High fat diet induced diabetic cardiomyopathy

29 September 2017

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Advanced glycation endproducts and diabetes. Beyond vascular complications

29 September 2017

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29 September 2017

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Obesity, insulin resistance and free fatty acids

29 September 2017

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Peroxisome Proliferator Activated Receptor-Alpha (PPARα) and PPAR Gamma Coactivator-1alpha (PGC-1α) Regulation of Cardiac Metabolism in Diabetes

29 September 2017

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Adipokines in inflammation and metabolic disease

29 September 2017

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Myo1c Regulates Glucose Uptake in Mouse Skeletal Muscle

29 September 2017

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Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

29 September 2017

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Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

29 September 2017

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Myocardial insulin resistance induced by high fat feeding in heart failure is associated with preserved contractile function.

29 September 2017

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Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective

29 September 2017

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29 September 2017

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29 September 2017

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Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

29 September 2017

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29 September 2017

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Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice

29 September 2017

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Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

29 September 2017

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29 September 2017

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29 September 2017

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Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity

29 September 2017

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Lipotoxicity in the heart

29 September 2017

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Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction

29 September 2017

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Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms

29 September 2017

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29 September 2017

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AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

29 September 2017

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Impaired insulin signaling accelerates cardiac mitochondrial dysfunction after myocardial infarction

29 September 2017

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Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

29 September 2017

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Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

29 September 2017

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29 September 2017

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Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

29 September 2017

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IRS1-independent defects define major nodes of insulin resistance

29 September 2017

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RAGE and modulation of ischemic injury in the diabetic myocardium

29 September 2017

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Insulin signalling in the heart

29 September 2017

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29 September 2017

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Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome

29 September 2017

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Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice

29 September 2017

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Diabetic cardiomyopathy revisited

29 September 2017

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Cardiovascular actions of insulin

29 September 2017

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Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

29 September 2017

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Myocardial substrate metabolism in the normal and failing heart

29 September 2017

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Fatty acid metabolism is enhanced in type 2 diabetic hearts

29 September 2017

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Inflammation, stress, and diabetes

29 September 2017

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Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

29 September 2017

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Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

29 September 2017

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Glucose transport in the heart

29 September 2017

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Heart failure: the frequent, forgotten, and often fatal complication of diabetes

29 September 2017

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Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

29 September 2017

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Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes

29 September 2017

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Lipoapoptosis: its mechanism and its diseases

29 September 2017

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Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase

29 September 2017

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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

29 September 2017

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The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus

29 September 2017

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

29 September 2017

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The insulin signaling system

29 September 2017

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Regulation of fatty acid oxidation in the mammalian heart in health and disease

29 September 2017

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Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans

29 September 2017

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Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments

29 September 2017

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Banting lecture 1988. Role of insulin resistance in human disease

29 September 2017

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Effects of acute hyperglycemia on myocardial glycolytic activity in humans

29 September 2017

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Elevated level of carbonyl compounds correlates with insulin resistance in type 2 diabetes

29 September 2017

1 reference

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Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart

27 June 2018

1 reference

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Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

27 June 2018

1 reference

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Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects

27 June 2018

1 reference

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In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle

27 June 2018

1 reference

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Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.

27 June 2018

1 reference

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Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: evidence from a 37,229 patient meta-analysis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Serum advanced glycation end products (AGEs) are associated with insulin resistance

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study

5 September 2018

1 reference

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Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases

5 September 2018

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Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Central role for aldose reductase pathway in myocardial ischemic injury

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated wi

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646067

Oxidative stress and heart failure

4 December 2018

1 reference

12 December 2020

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

1 reference

12 December 2020

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

12 December 2020

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

1 reference

12 December 2020

The metabolism of the heart

1 reference

12 December 2020

Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling

1 reference

12 December 2020

Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation

1 reference

12 December 2020

10.1161/ATVBAHA.111.241984

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895668%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895668%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

22895668

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895668%20AND%20SRC:MED&resulttype=core&format=json