Exploiting the defensive sugars of HIV-1 for drug and vaccine design (Q36802333)

16 August 2017

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title

Exploiting the defensive sugars of HIV-1 for drug and vaccine design (English)

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16 August 2017

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John Offer

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Christopher N Scanlan

series ordinal

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16 August 2017

Nicole Zitzmann

series ordinal

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16 August 2017

Raymond A Dwek

series ordinal

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16 August 2017

language of work or name

English

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publication date

1 April 2007

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16 August 2017

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inferred from page(s)

published in

Nature

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16 August 2017

volume

446

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16 August 2017

issue

7139

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16 August 2017

page(s)

1038-1045

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Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction

16 August 2017

cites work

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Electron microscopic and immunochemical analysis of the broadly neutralizing HIV-1-specific, anti-carbohydrate antibody, 2G12.

21 January 2018

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Viewing AIDS from a glycobiological perspective: potential linkages to the human fetoembryonic defence system hypothesis

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7 January 2021

Biases and complex patterns in the residues flanking protein N-glycosylation sites

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7 January 2021

O-GLYCBASE version 4.0: a revised database of O-glycosylated proteins

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7 January 2021

Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin

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7 January 2021

Antibody neutralization and escape by HIV-1

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7 January 2021

Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure

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7 January 2021

Structures of complement component C3 provide insights into the function and evolution of immunity

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7 January 2021

Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells

1 reference

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7 January 2021

Characterization of glycopeptides from HIV-I(SF2) gp120 by liquid chromatography mass spectrometry

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7 January 2021

Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus

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7 January 2021

The antigenic structure of the HIV gp120 envelope glycoprotein

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7 January 2021

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1 reference

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7 January 2021

The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

1 reference

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7 January 2021

Structure of an unliganded simian immunodeficiency virus gp120 core

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

The high degree of internal flexibility observed for an oligomannose oligosaccharide does not alter the overall topology of the molecule

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Structure of the Epstein-Barr virus major envelope glycoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection

1 reference

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7 January 2021

N-Linked Glycosylation of the HIV Type-1 gp120 Envelope Glycoprotein as a Major Determinant of CCR5 and CXCR4 Coreceptor Utilization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Inhibition of DC-SIGN-mediated trans infection of T cells by mannose-binding lectin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Interaction of mannose-binding lectin with HIV type 1 is sufficient for virus opsonization but not neutralization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR

1 reference

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7 January 2021

Dendritic-cell interactions with HIV: infection and viral dissemination

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

HIV gp120 receptors on human dendritic cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Nothing in glycobiology makes sense, except in the light of evolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Evolutionary considerations in relating oligosaccharide diversity to biological function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Evolution of the human ABO polymorphism by two complementary selective pressures.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

A genetic approach to Mammalian glycan function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

A role for carbohydrates in immune evasion in AIDS.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Removal of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

N-linked glycosylation of the V3 loop and the immunologically silent face of gp120 protects human immunodeficiency virus type 1 SF162 from neutralization by anti-gp120 and anti-gp41 antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Hsp90 as a capacitor of phenotypic variation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Evolutionary dynamics of the glycan shield of the human immunodeficiency virus envelope during natural infection and implications for exposure of the 2G12 epitope

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Consistent patterns of change during the divergence of human immunodeficiency virus type 1 envelope from that of the inoculated virus in simian/human immunodeficiency virus-infected macaques

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Role of protein disulfide isomerase and other thiol-reactive proteins in HIV-1 envelope protein-mediated fusion.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Roles of N-linked glycans in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Inhibition of HIV entry by carbohydrate-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Is resistance futile?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

GP120: target for neutralizing HIV-1 antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Antibody vs. HIV in a clash of evolutionary titans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Structural definition of a conserved neutralization epitope on HIV-1 gp120

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Identifying epitopes of HIV-1 that induce protective antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Toward a carbohydrate-based HIV-1 vaccine: synthesis and immunological studies of oligomannose-containing glycoconjugates

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Carbohydrate antigens: synthesis aspects and immunological applications in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Induction of IgG antibodies against the GD2 carbohydrate tumor antigen by vaccination with peptide mimotopes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Antigenic properties of peptide mimotopes of HIV-1-associated carbohydrate antigens.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Carbohydrate based vaccines

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Ganglioside mimicry as a cause of Guillain-Barré syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Overview of N- and O-linked oligosaccharide structures found in various yeast species

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

The immunobiology of Guillain-Barré syndromes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE05818

7 January 2021

Identifiers

DOI

10.1038/NATURE05818

1 reference

Dimensions Publication ID

16 August 2017

1047795661

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1 reference