The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis (Q36807931)

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scientific article published on 16 May 2008

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English	The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis	scientific article published on 16 May 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

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author name string

John J Lehman

1

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Europe PubMed Central

PMC publication ID

16 August 2017

Sihem Boudina

2

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Europe PubMed Central

PMC publication ID

16 August 2017

Natasha Hausler Banke

3

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Europe PubMed Central

PMC publication ID

16 August 2017

Nandakumar Sambandam

4

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Europe PubMed Central

PMC publication ID

16 August 2017

Xianlin Han

5

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Europe PubMed Central

PMC publication ID

16 August 2017

Deanna M Young

6

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Europe PubMed Central

PMC publication ID

16 August 2017

Teresa C Leone

7

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Europe PubMed Central

PMC publication ID

16 August 2017

Richard W Gross

8

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Europe PubMed Central

PMC publication ID

16 August 2017

E Douglas Lewandowski

9

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Europe PubMed Central

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16 August 2017

E Dale Abel

10

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16 August 2017

Daniel P Kelly

11

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Europe PubMed Central

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16 August 2017

publication date

16 May 2008

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16 August 2017

American Journal of Physiology Heart and Circulatory Physiology

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16 August 2017

295

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Europe PubMed Central

PMC publication ID

16 August 2017

1

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Europe PubMed Central

PMC publication ID

16 August 2017

H185-96

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Europe PubMed Central

PMC publication ID

16 August 2017

The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover

1 reference

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A fundamental system of cellular energy homeostasis regulated by PGC-1alpha

1 reference

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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Oxidative phosphorylation and aging

1 reference

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Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha

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Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice

1 reference

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

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PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

1 reference

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Mitochondrial energy metabolism in heart failure: a question of balance

1 reference

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

1 reference

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Mitochondria, oxidants, and aging

1 reference

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29 September 2017

Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle

1 reference

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29 September 2017

Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure

1 reference

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Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry

1 reference

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Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

1 reference

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

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PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

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Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

1 reference

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The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).

1 reference

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29 September 2017

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

1 reference

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29 September 2017

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

1 reference

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Nuclear activators and coactivators in mammalian mitochondrial biogenesis

1 reference

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29 September 2017

Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart

1 reference

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29 September 2017

Coupling of mitochondrial fatty acid uptake to oxidative flux in the intact heart

1 reference

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Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes

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Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart

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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

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cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats

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A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

1 reference

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Peroxisome proliferator-activated receptors: nuclear control of metabolism

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

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Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts

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DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein

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PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells

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Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo.

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Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13C NMR spectroscopy.

1 reference

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Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

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Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency.

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Accelerated triacylglycerol turnover kinetics in hearts of diabetic rats include evidence for compartmented lipid storage

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Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle

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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

1 reference

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Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium

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Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner

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Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

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Triacylglycerol turnover in isolated working hearts of acutely diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

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Regulation of energy metabolism of the heart during acute increase in heart work

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

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inferred from PubMed ID database lookup

Mitochondrial ATP synthesis in permeabilized cells: assessment of the ATP/O values in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

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Glucose and fatty acid metabolism in the isolated working mouse heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

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Myocardial Oxygen Consumption Is Unchanged but Efficiency Is Reduced in Patients With Essential Hypertension and Left Ventricular Hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

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Microsomal triglyceride transfer protein gene expression and triglyceride accumulation in hypoxic human hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

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Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPHEART.00081.2008

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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