T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number (Q36791953)

16 August 2017

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number (English)

1 reference

16 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046536%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Uchenna Emechebe

1 reference

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2 June 2020

Pavan Kumar P

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046536%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Julian M Rozenberg

1 reference

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2 June 2020

Bryn Moore

1 reference

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2 June 2020

Ashley Firment

1 reference

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2 June 2020

Tooraj Mirshahi

1 reference

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2 June 2020

language of work or name

English

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publication date

5 April 2016

1 reference

16 August 2017

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2 June 2020

volume

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describes a project that uses

2 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4829432/fullTextXML

inferred from PubMed Central ID database lookup

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Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex

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TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome

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Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome

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29 September 2017

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The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.

29 September 2017

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Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning

29 September 2017

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Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling

29 September 2017

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A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia

29 September 2017

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Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

29 September 2017

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The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

29 September 2017

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Self-renewing endodermal progenitor lines generated from human pluripotent stem cells

29 September 2017

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29 September 2017

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GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis

29 September 2017

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Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice

29 September 2017

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Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis

29 September 2017

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TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model

29 September 2017

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Gli proteins in development and disease

29 September 2017

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Complex interactions between genes controlling trafficking in primary cilia

29 September 2017

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KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes

29 September 2017

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Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen

29 September 2017

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SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

29 September 2017

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Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development

29 September 2017

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TBX2 and TBX3: the special value for anticancer drug targets.

29 September 2017

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Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

29 September 2017

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The primary cilium: a signalling centre during vertebrate development

29 September 2017

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Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development

29 September 2017

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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

29 September 2017

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Birth defects caused by mutations in human GLI3 and mouse Gli3 genes

29 September 2017

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Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

29 September 2017

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Tbx3 improves the germ-line competency of induced pluripotent stem cells

29 September 2017

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Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system

29 September 2017

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Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

29 September 2017

1 reference

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Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

29 September 2017

1 reference

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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

29 September 2017

1 reference

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A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Tbx3 is required for outflow tract development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

29 September 2017

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Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud

29 September 2017

1 reference

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Patched1 regulates hedgehog signaling at the primary cilium

29 September 2017

1 reference

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Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A guided tour into subcellular colocalization analysis in light microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

T-box genes in vertebrate development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

T-box genes in early embryogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Sonic hedgehog: restricted expression and limb dysmorphologies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Functions of FGF signalling from the apical ectodermal ridge in limb development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Fgf8 is required for outgrowth and patterning of the limbs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Dynamic association of proteasomal machinery with the centrosome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Generalized lacZ expression with the ROSA26 Cre reporter strain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Spatiotemporal regulation of GLI target genes in the mammalian limb bud.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

TBX3 Directs Cell-Fate Decision toward Mesendoderm

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Teratogenic action of carbonic anhydrase inhibitors in the rat

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Sufu and Kif7 in limb patterning and development

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

When right differs from left: human limb directional asymmetry emerges during very early development

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Sufu recruits GSK3beta for efficient processing of Gli3.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Tbx5 is dispensable for forelimb outgrowth.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4829432

Ulnar Mammary syndrome and TBX3: expanding the phenotype

5 September 2018

1 reference

12 December 2020

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

12 December 2020

DEFORMITY OF FORELIMB IN RATS: ASSOCIATION WITH HIGH DOSES OF ACETAZOLAMIDE

1 reference

12 December 2020

The molecular basis of Pallister Hall associated polydactyly

1 reference

12 December 2020

Valproic acid teratogenicity in whole embryo culture is not prevented by zinc supplementation

1 reference

12 December 2020

The toxicity of niridazole in rat embryos in vitro

1 reference

12 December 2020

Studies of malformation syndromes in man XXXXII: a pleiotropic dominant mutation affecting skeletal, sexual and apocrine-mammary development

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.07897

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046536%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046536%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

27046536

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27046536%20AND%20SRC:MED&resulttype=core&format=json