Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs (Q36795136)

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scientific article published on May 2007

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English	Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs	scientific article published on May 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

1 reference

Europe PubMed Central

Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

author name string

Bradley L Urquhart

1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Rommel G Tirona

2

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Richard B Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

publication date

1 May 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

The Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

566-578

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population. Reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs

1 reference

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21 January 2018

The role of individual human cytochromes P450 in drug metabolism and clinical response

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human drug metabolizing cytochromes P450.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of the novel splicing variants for the hPXR in human livers

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a novel polymorphic enhancer of the human CYP3A4 gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

1 reference

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21 January 2018

Variations of the human glucocorticoid receptor gene (NR3C1): Pathological and in vitro mutations and polymorphisms

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

1 reference

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21 January 2018

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1 reference

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21 January 2018

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Inherited disorders of bilirubin metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Pharmacological interventions for the treatment of neonatal jaundice.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transporters and drug therapy: implications for drug disposition and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Drug transport proteins in the liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

MRP2 and 3 in health and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

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21 January 2018

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

1 reference

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21 January 2018

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Breast cancer resistance protein (BCRP/ABCG2).

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Enterohepatic bile salt transporters in normal physiology and liver disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechan

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Multispecific amphipathic substrate transport by an organic anion transporter of human liver

1 reference

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21 January 2018

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

1 reference

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21 January 2018

Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma

1 reference

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21 January 2018

Nuclear receptors and the control of metabolism

1 reference

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21 January 2018

The nuclear receptor superfamily: a rosetta stone for physiology

1 reference

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21 January 2018

Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

1 reference

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21 January 2018

Pharmaceutical use of mouse models humanized for the xenobiotic receptor

1 reference

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21 January 2018

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

1 reference

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21 January 2018

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin

1 reference

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21 January 2018

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

1 reference

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21 January 2018

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

1 reference

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21 January 2018

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Functional analysis of four naturally occurring variants of human constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identifiers

10.1177/0091270007299930

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

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