Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects (Q36778228)

16 August 2017

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects (English)

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16 August 2017

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16 August 2017

Anne M Cataldo

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16 August 2017

Anne Boyer Boiteau

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16 August 2017

Linda C Hassinger

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16 August 2017

Corrinne M Peterhoff

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16 August 2017

Ying Jiang

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16 August 2017

Kerry Mullaney

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16 August 2017

Rachael L Neve

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16 August 2017

Jean Gruenberg

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16 August 2017

Ralph A Nixon

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16 August 2017

language of work or name

English

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publication date

5 June 2008

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The American Journal of Pathology

16 August 2017

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16 August 2017

173

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16 August 2017

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16 August 2017

370-384

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describes a project that uses

16 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2475775/fullTextXML

inferred from PubMed Central ID database lookup

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The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

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rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome

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Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies

29 September 2017

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29 September 2017

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Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40.

29 September 2017

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Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

29 September 2017

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Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

29 September 2017

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

29 September 2017

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Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

29 September 2017

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Characterization of the Endosomal Sorting Signal of the Cation-dependent Mannose 6-Phosphate Receptor

29 September 2017

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Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

29 September 2017

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Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking

29 September 2017

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Late endosome motility depends on lipids via the small GTPase Rab7.

29 September 2017

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Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis

29 September 2017

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

29 September 2017

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Localization of lysobisphosphatidic acid-rich membrane domains in late endosomes

29 September 2017

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Identification of discrete classes of endosome-derived small vesicles as a major cellular pool for recycling membrane proteins

29 September 2017

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Expression and properties of Rab4 and its effector rabaptin-4 in endocytic recycling

29 September 2017

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Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

29 September 2017

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The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

29 September 2017

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

29 September 2017

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beta 2-adrenergic receptor internalization, endosomal sorting, and plasma membrane recycling are regulated by rab GTPases

29 September 2017

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Rab7: a key to lysosome biogenesis

29 September 2017

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Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

29 September 2017

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Direct interaction of EEA1 with Rab5b

29 September 2017

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Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

29 September 2017

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Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.

29 September 2017

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Regulation of endosome fusion.

29 September 2017

1 reference

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The Rab5 effector EEA1 is a core component of endosome docking

29 September 2017

1 reference

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Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Microtubules are involved in bafilomycin A1-induced tubulation and Rab5-dependent vacuolation of early endosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Endosome-lysosomes, ubiquitin and neurodegeneration.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

The endosomal-lysosomal system of neurons: new roles

29 September 2017

1 reference

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The rab7 GTPase resides on a vesicular compartment connected to lysosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Rab 7: an important regulator of late endocytic membrane traffic

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Characterization of internalization and endosome formation of epidermal growth factor in transfected NIH-3T3 cells by computerized image-intensified three-dimensional fluorescence microscopy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

29 September 2017

1 reference

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rab5 controls early endosome fusion in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Molecular mapping of Alzheimer-type dementia in Down's syndrome

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Rab7 regulates transport from early to late endocytic compartments in Xenopus oocytes

27 June 2018

1 reference

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Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration

27 June 2018

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Structure-function relationship of the small GTPase rab5.

27 June 2018

1 reference

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Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections

27 June 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

5 September 2018

1 reference

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Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease

5 September 2018

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Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

5 September 2018

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Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

5 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

The Two Mannose 6-Phosphate Receptors Transport Distinct Complements of Lysosomal Proteins

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2475775

Calcium-containing endosomes at oculomotor terminals in animal models of ALS

5 September 2018

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12 December 2020

Expression of multiple proteins within single primary cortical neurons using a replication deficient HSV vector

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12 December 2020

Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1

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12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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12 December 2020

Rab4 affects both recycling and degradative endosomal trafficking

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12 December 2020

The neuronal endosomal-lysosomal system in Alzheimer's disease

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12 December 2020

10.2353/AJPATH.2008.071053

Identifiers

DOI

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

18535180

1 reference