Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases (Q36775280)

16 August 2017

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title

Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases (English)

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16 August 2017

Trevor T Hansel

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16 August 2017

Roy Pettipher

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16 August 2017

Richard Armer

series ordinal

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16 August 2017

publication date

1 April 2007

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Nature Reviews Drug Discovery

16 August 2017

published in

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

313-325

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Prostaglandin D2 and sleep regulation

16 August 2017

cites work

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31 March 2020

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Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets

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Increased urinary excretion of the prostaglandin D2 metabolite 9 alpha, 11 beta-prostaglandin F2 after aspirin challenge supports mast cell activation in aspirin-induced airway obstruction

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Monitoring mast cell activation by prostaglandin D2 in vivo

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31 March 2020

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31 March 2020

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Inflammatory mediators in late antigen-induced rhinitis

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

31 March 2020

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Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes

31 March 2020

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Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis

31 March 2020

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15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils

31 March 2020

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9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2

31 March 2020

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11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils

31 March 2020

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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

31 March 2020

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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

31 March 2020

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Activation of nuclear receptors by prostaglandins

31 March 2020

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Inflammatory effects of prostaglandin D2 in rat and human skin

31 March 2020

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31 March 2020

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Role of prostaglandin-mediated vasodilatation in inflammation

31 March 2020

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The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist

31 March 2020

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31 March 2020

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Prostaglandin D2 causes accumulation of eosinophils in the lumen of the dog trachea

31 March 2020

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Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice

31 March 2020

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Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

31 March 2020

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CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

31 March 2020

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Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptors

31 March 2020

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Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans

31 March 2020

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9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways

31 March 2020

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Prostaglandin D2 as a mediator of allergic asthma

31 March 2020

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Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa

31 March 2020

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Effects of intravenous infusions of prostaglandin D2 in man

31 March 2020

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Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy

31 March 2020

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The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage.

31 March 2020

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Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans

31 March 2020

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Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1.

31 March 2020

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Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways

31 March 2020

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Prostaglandin D2 affects the differentiation and functions of human dendritic cells: impact on the T cell response.

31 March 2020

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Effects of prostaglandin D2 on helper T cell functions

31 March 2020

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Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells

31 March 2020

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Inducible cyclooxygenase may have anti-inflammatory properties

31 March 2020

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Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis

31 March 2020

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Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity

31 March 2020

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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro

31 March 2020

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BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro

31 March 2020

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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats

31 March 2020

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Effects of thromboxane A2 receptor antagonist (Bay u 3405) on nasal symptoms after antigen challenge in sensitized guinea pigs

31 March 2020

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The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions

31 March 2020

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CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation

31 March 2020

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A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants

31 March 2020

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Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse

31 March 2020

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Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.

31 March 2020

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Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment

31 March 2020

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Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family

31 March 2020

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Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

31 March 2020

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Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.

31 March 2020

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Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity

31 March 2020

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Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses

31 March 2020

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The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men.

31 March 2020

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Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction.

31 March 2020

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The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations

31 March 2020

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Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction

31 March 2020

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Effect of thromboxane A2-receptor antagonist on bradykinin-induced bronchoconstriction in asthma

31 March 2020

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Effects of a thromboxane receptor antagonist on prostaglandin D2 and histamine induced bronchoconstriction in man

31 March 2020

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Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma

31 March 2020

1 reference

The effects of an anti-CD18 antibody (R15.7) in antigen-induced airway hyperresponsiveness (AH) and cell influx in guinea pigs

31 March 2020

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BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmatics

31 March 2020

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Effect of indomethacin on allergen-induced asthmatic responses

31 March 2020

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Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release

31 March 2020

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Effect of Inhaled Prostaglandin E2on Allergen-induced Asthma

31 March 2020

1 reference

Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib

31 March 2020

1 reference

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31 March 2020

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Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma

31 March 2020

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

31 March 2020

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IL-5-induced airway eosinophilia--the key to asthma?

31 March 2020

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Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability

31 March 2020

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Role of prostanoid DP receptor variants in susceptibility to asthma

31 March 2020

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Emerging roles of DP and CRTH2 in allergic inflammation

31 March 2020

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Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases

31 March 2020

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Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview

31 March 2020

1 reference

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

31 March 2020

1 reference

Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2

31 March 2020

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Expression and Molecular Pharmacology of the Mouse CRTH2 Receptor

31 March 2020

1 reference

Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.

31 March 2020

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A physicogenetic method to assign ligand-binding relationships between 7TM receptors

31 March 2020

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Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2

31 March 2020

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Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.

31 March 2020

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Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

31 March 2020

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On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

31 March 2020

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Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists

31 March 2020

1 reference

Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.

31 March 2020

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Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

31 March 2020

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Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRD2266

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release_v5oyduxd2re3rciukgeq4udq24

16 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/v5oyduxd2re3rciukgeq4udq24

mapped directly with Wikidata item

24 November 2022

based on heuristic

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