Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies (Q36750045)

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27 February 2020

title

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies (English)

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27 February 2020

1 reference

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27 February 2020

William R Schief

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27 February 2020

Johannes F Scheid

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27 February 2020

Leonidas Stamatatos

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27 February 2020

Sam Hoot

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27 February 2020

Anita M Dreyer

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27 February 2020

Adriana Lippy

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27 February 2020

Andrew Stuart

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27 February 2020

Kristen W Cohen

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27 February 2020

Joseph Jardine

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27 February 2020

Sergey Menis

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27 February 2020

Anthony P West

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27 February 2020

language of work or name

English

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publication date

25 March 2013

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Journal of Experimental Medicine

27 February 2020

published in

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27 February 2020

volume

210

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27 February 2020

issue

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27 February 2020

page(s)

655-663

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Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

27 February 2020

cites work

1 reference

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Anti-HIV B Cell lines as candidate vaccine biosensors

29 September 2017

1 reference

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Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

29 September 2017

1 reference

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Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.

29 September 2017

1 reference

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HIV vaccine design: the neutralizing antibody conundrum

29 September 2017

1 reference

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The development of CD4 binding site antibodies during HIV-1 infection

29 September 2017

1 reference

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Increasing the potency and breadth of an HIV antibody by using structure-based rational design

29 September 2017

1 reference

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RosettaRemodel: a generalized framework for flexible backbone protein design.

29 September 2017

1 reference

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

29 September 2017

1 reference

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

29 September 2017

1 reference

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Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.

29 September 2017

1 reference

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Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study

29 September 2017

1 reference

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The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3620356

Characteristics of the earliest cross-neutralizing antibody response to HIV-1.

29 September 2017

1 reference

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

29 September 2017

1 reference

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

29 September 2017

1 reference

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The role of antibodies in HIV vaccines

29 September 2017

1 reference

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Challenges for structure-based HIV vaccine design

29 September 2017

1 reference

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Improving the expression of recombinant soluble HIV Envelope glycoproteins using pseudo-stable transient transfection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3620356

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens

29 September 2017

1 reference

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Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

29 September 2017

1 reference

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Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

29 September 2017

1 reference

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Broad HIV-1 neutralization mediated by CD4-binding site antibodies

29 September 2017

1 reference

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IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta

29 September 2017

1 reference

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Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors

29 September 2017

1 reference

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The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner

29 September 2017

1 reference

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V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3620356

Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions

29 September 2017

1 reference

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A distinct signaling pathway used by the IgG-containing B cell antigen receptor

29 September 2017

1 reference

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5 September 2018

Identifiers

DOI

10.1084/JEM.20122824

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23530120%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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27 February 2020

PubMed publication ID

23530120

1 reference

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