EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy (Q36758325)

16 August 2017

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title

EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy (English)

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16 August 2017

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D Irmer

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16 August 2017

J O Funk

series ordinal

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16 August 2017

A Blaukat

series ordinal

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16 August 2017

language of work or name

English

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publication date

12 March 2007

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16 August 2017

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

5693-5701

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Enhancement of sensitivity to tumor necrosis factor alpha in non-small cell lung cancer cells with acquired resistance to gefitinib

16 August 2017

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7 January 2021

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7 January 2021

An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

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Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

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7 January 2021

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

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7 January 2021

Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

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7 January 2021

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

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7 January 2021

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

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7 January 2021

SH2 domains, interaction modules and cellular wiring

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7 January 2021

The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy

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7 January 2021

Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations

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7 January 2021

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

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7 January 2021

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

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7 January 2021

Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib

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7 January 2021

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7 January 2021

Unraveling the mystery of prognostic and predictive factors in epidermal growth factor receptor therapy

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7 January 2021

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

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7 January 2021

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

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7 January 2021

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7 January 2021

Autocrine, paracrine and juxtacrine signaling by EGFR ligands

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7 January 2021

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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7 January 2021

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7 January 2021

EGFR mutation and response of lung cancer to gefitinib

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7 January 2021

Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255.

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7 January 2021

Erlotinib in lung cancer - molecular and clinical predictors of outcome

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7 January 2021

Responsiveness to cetuximab without mutations in EGFR.

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7 January 2021

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

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7 January 2021

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210383

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Dimensions Publication ID

16 August 2017

1050198010

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