Molecular therapy in the microRNA era. (Q36692835)

15 August 2017

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title

Molecular therapy in the microRNA era. (English)

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15 August 2017

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Wurdinger T

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15 August 2017

Costa FF

series ordinal

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15 August 2017

publication date

26 December 2006

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The Pharmacogenomics Journal

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

297-304

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Non–coding RNA genes and the modern RNA world

15 August 2017

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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MicroRNAs in cell proliferation, cell death, and tumorigenesis.

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Oncomirs - microRNAs with a role in cancer

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A biochemical framework for RNA silencing in plants

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siRNAs can function as miRNAs

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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Short RNAs repress translation after initiation in mammalian cells.

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microRNA target predictions in animals

21 January 2018

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs

21 January 2018

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A brain-specific microRNA regulates dendritic spine development

21 January 2018

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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

21 January 2018

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The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

21 January 2018

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miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation

21 January 2018

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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

21 January 2018

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Accumulation of miR-155 and BIC RNA in human B cell lymphomas

21 January 2018

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A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors

21 January 2018

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c-Myc-regulated microRNAs modulate E2F1 expression

21 January 2018

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MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts

21 January 2018

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MicroRNA expression profiles classify human cancers

21 January 2018

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A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

21 January 2018

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A microRNA expression signature of human solid tumors defines cancer gene targets

21 January 2018

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Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice

21 January 2018

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Progress in the use of microarray technology to study the neurobiology of disease

21 January 2018

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Molecular portraits and the family tree of cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Microarray analysis of microRNA expression in the developing mammalian brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A microRNA array reveals extensive regulation of microRNAs during brain development

21 January 2018

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An optimized isolation and labeling platform for accurate microRNA expression profiling.

21 January 2018

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Microarray-based, high-throughput gene expression profiling of microRNAs

21 January 2018

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A custom microarray platform for analysis of microRNA gene expression

21 January 2018

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Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

21 January 2018

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An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe

21 January 2018

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MicroRNA expression detected by oligonucleotide microarrays: system establishment and expression profiling in human tissues

21 January 2018

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Probing microRNAs with microarrays: tissue specificity and functional inference

21 January 2018

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21 January 2018

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21 January 2018

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Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies

21 January 2018

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21 January 2018

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21 January 2018

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MicroRNA expression profiling of single whole embryonic stem cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

21 January 2018

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21 January 2018

MicroRNAs as oncogenes

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Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A microRNA polycistron as a potential human oncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Noncoding RNAs in the mammalian central nervous system.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Sequence variants in SLITRK1 are associated with Tourette's syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

MicroRNA-143 regulates adipocyte differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A pancreatic islet-specific microRNA regulates insulin secretion

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A cellular microRNA mediates antiviral defense in human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Building mammalian signalling pathways with RNAi screens

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Progress towards in vivo use of siRNAs

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Off-target effects by siRNA can induce toxic phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Revealing the world of RNA interference

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Microarray technology: beyond transcript profiling and genotype analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Improved targeting of miRNA with antisense oligonucleotides

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Mechanisms of gene silencing by double-stranded RNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Sequence-specific inhibition of small RNA function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

LNA-modified oligonucleotides mediate specific inhibition of microRNA function.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

MicroRNA expression in zebrafish embryonic development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

21 January 2018

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siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Micro RNAs in animal development.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Making sense of antisense

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

Noise amidst the silence: off-target effects of siRNAs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

MicroRNAs as oncogenes and tumor suppressors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

7 January 2021

DNA array-based gene profiling: from surgical specimen to the molecular portrait of cancer

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

7 January 2021

A single-molecule method for the quantitation of microRNA gene expression

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

7 January 2021

MicroRNA in chronic lymphocytic leukemia

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

7 January 2021

Clarifications on miRNA and cancer

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https://api.crossref.org/works/10.1038%2FSJ.TPJ.6500429

7 January 2021

Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript

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7 January 2021

In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes

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7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500429

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15 August 2017

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