A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers. (Q36677916)

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scientific article published on 18 May 2012

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English	A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers.	scientific article published on 18 May 2012

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scholarly article

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Europe PubMed Central

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1 February 2020

A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610501%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Sailendra Nichenametla

1

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1 February 2020

author name string

Joshua E Muscat

2

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1 February 2020

Jason G Liao

3

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1 February 2020

Philip Lazarus

4

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1 February 2020

John P Richie

5

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1 February 2020

publication date

18 May 2012

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1 February 2020

Molecular Carcinogenesis

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1 February 2020

52

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1 February 2020

10

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1 February 2020

791-799

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1 February 2020

A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Interaction of GAG trinucleotide repeat and C-129T polymorphisms impairs expression of the glutamate-cysteine ligase catalytic subunit gene

1 reference

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Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk

1 reference

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Blood iron, glutathione, and micronutrient levels and the risk of oral cancer

1 reference

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30 September 2017

Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence

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30 September 2017

The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer

1 reference

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30 September 2017

Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease

1 reference

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30 September 2017

Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review

1 reference

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Free radicals, metals and antioxidants in oxidative stress-induced cancer

1 reference

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30 September 2017

The importance of glutathione in human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

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30 September 2017

Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Blood glutathione decreases in chronic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Inhibition of oral carcinogenesis by glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Persistent oxidative stress in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

The role of glutathione and glutathione transferases in chemical carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Inhibition of carcinogenesis by minor dietary constituents

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30 September 2017

Low blood glutathione levels in healthy aging adults

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

30 September 2017

Dietary glutathione intake and the risk of oral and pharyngeal cancer

1 reference

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28 June 2018

The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3595361

28 June 2018

In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds

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28 June 2018

Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

Ethnic diversity in a critical gene responsible for glutathione synthesis.

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

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Determination of thiols and disulfides using high-performance liquid chromatography with electrochemical detection.

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

Glutathione pathway genes and lung cancer risk in young and old populations.

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

Short tandem repeat polymorphism evolution in humans

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung.

1 reference

https://api.crossref.org/works/10.1002%2FMC.21923

21 January 2018

Transient depletion of lung glutathione by diethylmaleate enhances oxygen toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22610501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal alveolar epithelial lining fluid contains high levels of glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/22610501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in glutathione-related genes affect methylmercury retention

1 reference

https://pubmed.ncbi.nlm.nih.gov/22610501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic beryllium disease and glutathione biosynthesis genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22610501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22610501

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/MC.21923

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610501%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610501%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22610501%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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