Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma (Q36642956)

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scientific article published on February 2016

Language	Label	Description	Also known as
English	Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma	scientific article published on February 2016

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

multiple myeloma

1 reference

based on heuristic

inferred from title

Teresita M. Bellido

11

object named as

Teresita Bellido

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Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Jesus Delgado-Calle

1

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Europe PubMed Central

PMC publication ID

15 August 2017

Judith Anderson

2

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Europe PubMed Central

PMC publication ID

15 August 2017

Meloney D Cregor

3

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Europe PubMed Central

PMC publication ID

15 August 2017

Masahiro Hiasa

4

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Europe PubMed Central

PMC publication ID

15 August 2017

John M Chirgwin

5

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Europe PubMed Central

PMC publication ID

15 August 2017

Nadia Carlesso

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Toshiyuki Yoneda

7

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Europe PubMed Central

PMC publication ID

15 August 2017

Khalid S Mohammad

8

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Europe PubMed Central

PMC publication ID

15 August 2017

Lilian I Plotkin

9

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Europe PubMed Central

PMC publication ID

15 August 2017

G David Roodman

10

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Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 February 2016

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Europe PubMed Central

PMC publication ID

15 August 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

15 August 2017

76

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Europe PubMed Central

PMC publication ID

15 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1089-1100

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Europe PubMed Central

PMC publication ID

15 August 2017

FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Pathogenesis beyond the cancer clone(s) in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

High bone mass in mice lacking Cx37 because of defective osteoclast differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Osteocyte-driven bone remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Activation of Wnt/β-catenin signaling increases apoptosis in melanoma cells treated with trail

1 reference

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30 September 2017

WNT signaling in bone homeostasis and disease: from human mutations to treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Notch-directed microenvironment reprogramming in myeloma: a single path to multiple outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Osteocyte control of osteoclastogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Sclerostin is overexpressed by plasma cells from multiple myeloma patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

The amazing osteocyte

1 reference

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30 September 2017

Combined Inhibition of Notch Signaling and Bcl-2/Bcl-xL Results in Synergistic Antimyeloma Effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Targeting the bone microenvironment in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Control of bone mass and remodeling by PTH receptor signaling in osteocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Chemokines in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Notch signalling: a simple pathway becomes complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Characterization of the MM.1 human multiple myeloma (MM) cell lines: a model system to elucidate the characteristics, behavior, and signaling of steroid-sensitive and -resistant MM cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Establishment of an osteoid preosteocyte-like cell MLO-A5 that spontaneously mineralizes in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Establishment of an osteocyte-like cell line, MLO-Y4.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

30 September 2017

Notch1 overexpression promotes cell growth and tumor angiogenesis in myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Elevated circulating sclerostin correlates with advanced disease features and abnormal bone remodeling in symptomatic myeloma: reduction post-bortezomib monotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Pathogenesis of myeloma bone disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4775415

20 September 2018

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

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20 September 2018

Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

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https://pubmed.ncbi.nlm.nih.gov/26833121

12 December 2020

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Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26833121

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apoptosis of bone cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26833121

12 December 2020

based on heuristic

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Methodological assessment of acid-etching for visualizing the osteocyte lacunar-canalicular networks using scanning electron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26833121

12 December 2020

based on heuristic

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Identifiers

10.1158/0008-5472.CAN-15-1703

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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