A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type (Q36640327)

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scientific article published on 14 January 2016

Language	Label	Description	Also known as
English	A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type	scientific article published on 14 January 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

A novel AKT inhibitor, AZD5363, inhibits phosphorylation of AKT downstream molecules, and activates phosphorylation of mTOR and SMG-1 dependent on the liver cancer cell type (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

phosphorylation

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Yuncheng Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yuanwen Zheng

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Ali Faheem

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Tiantong Sun

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Chunyou Li

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Zhe Li

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Diantang Zhao

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Chao Wu

8

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jun Liu

9

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

publication date

14 January 2016

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Oncology Letters

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1685-1692

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models

1 reference

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Smg1 haploinsufficiency predisposes to tumor formation and inflammation

1 reference

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Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies

1 reference

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Mammalian target of rapamycin signaling in diabetic cardiovascular disease

1 reference

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SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians

1 reference

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30 September 2017

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background

1 reference

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Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.

1 reference

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30 September 2017

Hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

1 reference

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1 reference

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Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo

1 reference

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Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question

1 reference

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Management of hepatocellular carcinoma: An update

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Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders

1 reference

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Global cancer statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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The Akt-specific inhibitor MK2206 selectively inhibits thyroid cancer cells harboring mutations that can activate the PI3K/Akt pathway

1 reference

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

1 reference

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Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

30 September 2017

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages

1 reference

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30 September 2017

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

1 reference

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

1 reference

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AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

30 September 2017

Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

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Pivotal role of mTOR signaling in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

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A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans

1 reference

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

1 reference

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A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis

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The two TORCs and Akt.

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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

1 reference

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1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4774473

30 September 2017

SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

1 reference

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1 reference

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Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

1 reference

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30 September 2017

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1 reference

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Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

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12 December 2020

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10.3892/OL.2016.4111

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24 November 2022

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PMC publication ID

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Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

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Europe PubMed Central

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15 August 2017

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