Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). (Q36618965)

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scientific article published on February 1999

Language	Label	Description	Also known as
English	Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG).	scientific article published on February 1999

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Kuin A

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Aalders M

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Lamfers M

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

van Zuidam DJ

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Essers M

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Beijnen JH

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Smets LA

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 February 1999

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

79

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Europe PubMed Central

PMC publication ID

15 August 2017

5-6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

793-801

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Molecular targeting of mitomycin C chemotherapy

1 reference

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30 September 2017

The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects

1 reference

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30 September 2017

pH in human tumour xenografts: effect of intravenous administration of glucose

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Melphalan tissue concentrations in patients treated with regional isolated perfusion for melanoma of the lower limb

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In vivo metabolic effects of hyperglycemia in murine radiation-induced fibrosarcoma: a 31P NMR investigation

1 reference

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The relevance of tumour pH to the treatment of malignant disease

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Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

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In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

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30 September 2017

Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours

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30 September 2017

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Thermosensitization by increasing intracellular acidity with amiloride and its analogs.

1 reference

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Cellular pharmacokinetics and cytotoxicity of camptothecin and topotecan at normal and acidic pH

1 reference

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28 June 2018

Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

1 reference

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28 June 2018

A new mouse tumor model system (RIF-1) for comparison of end-point studies

1 reference

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28 June 2018

Extracellular pH, transmembrane distribution and cytotoxicity of chlorambucil.

1 reference

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28 June 2018

Influence of microenvironmental pH on adriamycin resistance.

1 reference

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28 June 2018

Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone.

1 reference

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28 June 2018

Modulation of murine radiation-induced fibrosarcoma-1 tumor metabolism and blood flow in situ via glucose and mannitol administration monitored by 31P and 2H nuclear magnetic resonance spectroscopy

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28 June 2018

Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Reduction of intratumoral pH by the mitochondrial inhibitor m-iodobenzylguanidine and moderate hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of chlorambucil cytotoxicity by combination with flavone acetic acid in a murine tumour

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of tumour intracellular pH and enhancement of melphalan cytotoxicity by the ionophore Nigericin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

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EO9 phase II study in advanced breast, gastric, pancreatic and colorectal carcinoma by the EORTC Early Clinical Studies Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical characterization and comparative cellular effects of meta-iodobenzyl guanidine and benzyl guanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renal toxicity of the neuron-blocking and mitochondriotropic agent m-iodobenzylguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphofructokinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic basis for the comparative antitumour activity and toxicity of chlorambucil, phenylacetic acid mustard and beta, beta-difluorochlorambucil (CB 7103) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

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Proton-mediated liberation of aldophosphamide from a nontoxic prodrug: a strategy for tumor-selective activation of cytocidal drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

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based on heuristic

inferred from PubMed ID database lookup

Impaired mitochondrial respiration and stimulated glycolysis by m-iodobenzylguanidine (MIBG)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of hypoxia and low pH on the cytotoxicity of chlorambucil

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

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Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of human tumor pH by elevation of blood glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/10070871

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6690127

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

ResearchGate publication ID

0 references

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