Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening (Q36583015)

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scientific article published on 16 February 2016

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English	Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening	scientific article published on 16 February 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening (English)

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Europe PubMed Central

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15 August 2017

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Brady J Maher

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Europe PubMed Central

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15 August 2017

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Andrew E Jaffe

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Daniel J Hoeppner

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Daniel J Hoeppner

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15 August 2017

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Nicholas E Calcaterra

1

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15 August 2017

Huijun Wei

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15 August 2017

James C Barrow

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15 August 2017

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publication date

16 February 2016

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15 August 2017

Scientific Reports

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15 August 2017

6

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15 August 2017

19976

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Europe PubMed Central

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15 August 2017

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Creative Commons Attribution 4.0 International

16 February 2016

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April 2022 Public Data File from Crossref

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Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

1 reference

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Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects

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Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

1 reference

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Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2.

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Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels

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Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum

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The eag domain regulates hERG channel inactivation gating via a direct interaction

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The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations.

1 reference

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hERG K(+) channels: structure, function, and clinical significance

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Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

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Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels

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Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.

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Trafficking Defect and Proteasomal Degradation Contribute to the Phenotype of a Novel KCNH2 Long QT Syndrome Mutation

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Hsp40 chaperones promote degradation of the HERG potassium channel

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10.1038/SREP19976

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Europe PubMed Central

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15 August 2017

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PMC publication ID

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Europe PubMed Central

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15 August 2017

PubMed publication ID

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15 August 2017

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