Mechanism of transcriptional activation by the Myc oncoproteins (Q36578696)

15 August 2017

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title

Mechanism of transcriptional activation by the Myc oncoproteins (English)

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15 August 2017

Victoria H Cowling

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15 August 2017

Michael D Cole

series ordinal

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15 August 2017

publication date

4 August 2006

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Seminars in Cancer Biology

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

242-252

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

15 August 2017

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

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TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins

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TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

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Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium

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ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

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Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

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Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex

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Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo

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Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

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Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter

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Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.

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Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators

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c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

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Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.

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c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism

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Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

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AAA proteins. Lords of the ring

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Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins

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A chromatin remodelling complex involved in transcription and DNA processing.

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Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.

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Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors

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Recent highlights of RNA-polymerase-II-mediated transcription

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The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

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2 April 2022

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Targets of the Gal4 transcription activator in functional transcription complexes.

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Binding of myc proteins to canonical and noncanonical DNA sequences

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Analysis of genomic targets reveals complex functions of MYC.

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An amino-terminal c-myc domain required for neoplastic transformation activates transcription

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NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Coexamination of site-specific transcription factor binding and promoter activity in living cells

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2 April 2022

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Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis

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A conserved element in Myc that negatively regulates its proapoptotic activity

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Genomic targets of the human c-Myc protein

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest.

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2 April 2022

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TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis

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2 April 2022

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Myc influences global chromatin structure.

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2 April 2022

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Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

The p400 complex is an essential E1A transformation target

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

The Max network gone mad.

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Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex

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A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

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An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

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Definition of regions in human c-myc that are involved in transformation and nuclear localization

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2 April 2022

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Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein

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Function of a eukaryotic transcription activator during the transcription cycle

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ESA1 is a histone acetyltransferase that is essential for growth in yeast

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A role for c-Myc in the regulation of ribosomal RNA processing

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Parsing Ink4a/Arf: "pure" p16-null mice

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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

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Ras enhances Myc protein stability.

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Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1.

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Functional analysis of the N-terminal domain of the Myc oncoprotein

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Induction of apoptosis in fibroblasts by c-myc protein

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

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2 April 2022

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

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2 April 2022

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Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

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The language of covalent histone modifications

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

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2 April 2022

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In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer

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2 April 2022

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N and C-terminal sub-regions in the c-Myc transactivation region and their joint role in creating versatility in folding and binding

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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Posttranscriptional regulation of cellular gene expression by the c-myc oncogene

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2 April 2022

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The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Complementation of Myc-dependent cell proliferation by cDNA expression library screening

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Emerging roles of ubiquitin in transcription regulation

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2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes.

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Sequence-specific DNA binding by the c-Myc protein

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

p19ARF directly and differentially controls the functions of c-Myc independently of p53.

1 reference

2 April 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.SEMCANCER.2006.08.001

Identifiers

DOI

10.1016/J.SEMCANCER.2006.08.001

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15 August 2017

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