Balancing co-stimulation and inhibition with BTLA and HVEM. (Q36577555)

15 August 2017

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title

Balancing co-stimulation and inhibition with BTLA and HVEM. (English)

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15 August 2017

Kenneth M Murphy

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15 August 2017

Christopher A Nelson

series ordinal

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15 August 2017

John R Sedý

series ordinal

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15 August 2017

publication date

1 September 2006

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Nature Reviews Immunology

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

671-681

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An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection

15 August 2017

cites work

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B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells

21 January 2018

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Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor

21 January 2018

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The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity

21 January 2018

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Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction

21 January 2018

1 reference

CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases

21 January 2018

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Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

21 January 2018

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Regulation of T lymphocyte metabolism

21 January 2018

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SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

21 January 2018

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A TNF family member LIGHT transduces costimulatory signals into human T cells

21 January 2018

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LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide

21 January 2018

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Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.

21 January 2018

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Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation

21 January 2018

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Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts.

21 January 2018

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21 January 2018

The B7-CD28 superfamily

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31 March 2020

The B7 family revisited

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

31 March 2020

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TNF/TNFR family members in costimulation of T cell responses

31 March 2020

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Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

31 March 2020

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Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family

31 March 2020

1 reference

ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5

31 March 2020

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Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1

31 March 2020

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A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation

31 March 2020

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LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

31 March 2020

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The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

31 March 2020

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The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells

31 March 2020

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A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis

31 March 2020

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

31 March 2020

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The molecular architecture of the TNF superfamily

31 March 2020

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The three HveA receptor ligands, gD, LT-alpha and LIGHT bind to distinct sites on HveA.

31 March 2020

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Localization of the gD-binding region of the human herpes simplex virus receptor, HveA

31 March 2020

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Herpes simplex virus glycoprotein D bound to the human receptor HveA

31 March 2020

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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

31 March 2020

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B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

31 March 2020

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A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

31 March 2020

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Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway

31 March 2020

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Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex

31 March 2020

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Proteomic profiling of surface proteins on Th1 and Th2 cells

31 March 2020

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Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells

31 March 2020

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Mouse T cells receive costimulatory signals from LIGHT, a TNF family member

31 March 2020

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LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

31 March 2020

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LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation.

31 March 2020

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The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses

31 March 2020

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A molecular perspective of CTLA-4 function

31 March 2020

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Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

31 March 2020

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

31 March 2020

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Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

31 March 2020

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Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

31 March 2020

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Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

31 March 2020

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Molecular basis of T cell inactivation by CTLA-4

31 March 2020

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Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

31 March 2020

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A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling

31 March 2020

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail

31 March 2020

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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

31 March 2020

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T-cell regulation by CD28 and CTLA-4.

31 March 2020

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The use of okadaic acid to elucidate the intracellular role(s) of protein phosphatase 2A: lessons from the mast cell model system

31 March 2020

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Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

31 March 2020

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Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

31 March 2020

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Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo

31 March 2020

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Structural and functional analysis of the costimulatory receptor programmed death-1.

31 March 2020

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

31 March 2020

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

31 March 2020

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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

31 March 2020

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

31 March 2020

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Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA.

31 March 2020

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Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2.

31 March 2020

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Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells

31 March 2020

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Restoring function in exhausted CD8 T cells during chronic viral infection

31 March 2020

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Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth

31 March 2020

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LIGHT-HVEM signaling and the regulation of T cell-mediated immunity

31 March 2020

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Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues

31 March 2020

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

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Priming of naive T cells inside tumors leads to eradication of established tumors

31 March 2020

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The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues

31 March 2020

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Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion

31 March 2020

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LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM.

31 March 2020

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NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors

31 March 2020

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The critical role of LIGHT, a TNF family member, in T cell development

31 March 2020

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Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy

31 March 2020

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Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival

31 March 2020

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Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

31 March 2020

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LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function.

31 March 2020

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

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An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

31 March 2020

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CD40 ligand-transduced co-stimulation of T cells in the development of helper function

31 March 2020

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Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

31 March 2020

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Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

31 March 2020

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LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway

31 March 2020

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LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer

31 March 2020

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CTLA4 gene polymorphism and autoimmunity

31 March 2020

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PD-1/PD-L pathway and autoimmunity

31 March 2020

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Haplotype analysis of tumour necrosis factor receptor genes in 1p36: no evidence for association with systemic lupus erythematosus

31 March 2020

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Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1917

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release_vm5ovuogrvgdhb4td2gwj77qwu

15 August 2017

Fatcat ID

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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