Inhibitors of mitotic kinesins: next-generation antimitotics (Q36558125)

14 August 2017

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title

Inhibitors of mitotic kinesins: next-generation antimitotics (English)

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14 August 2017

Vasiliki Sarli

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14 August 2017

Athanassios Giannis

series ordinal

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14 August 2017

publication date

1 March 2006

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14 August 2017

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

293-298

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Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents

14 August 2017

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The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line

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Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference

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Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

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7 January 2021

Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix

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7 January 2021

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The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

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The mechanism, function and regulation of depolymerizing kinesins during mitosis.

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CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

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The Second Microtubule-binding Site of Monomeric Kid Enhances the Microtubule Affinity

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Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis

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Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells

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7 January 2021

Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2

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7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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7 January 2021

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

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7 January 2021

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

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7 January 2021

Inhibition of a mitotic motor protein: where, how, and conformational consequences

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7 January 2021

Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5.

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7 January 2021

Synthesis and biological evaluation of novel EG5 inhibitors

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7 January 2021

A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.

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7 January 2021

Antitumor activity of a kinesin inhibitor

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7 January 2021

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

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7 January 2021

HR22C16: a potent small-molecule probe for the dynamics of cell division

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7 January 2021

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

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7 January 2021

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

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7 January 2021

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

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7 January 2021

Differential effects of monastrol in two human cell lines

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7 January 2021

Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

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7 January 2021

The spindle checkpoint: structural insights into dynamic signalling

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Depletion of a microtubule-associated motor protein induces the loss of dendritic identity

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7 January 2021

Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development.

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7 January 2021

Expression of the mitotic kinesin Kif15 in postmitotic neurons: Implications for neuronal migration and development

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7 January 2021

Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons

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7 January 2021

Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200500045

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14 August 2017

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