The makings of maleness: towards an integrated view of male sexual development (Q36532967)

14 August 2017

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title

The makings of maleness: towards an integrated view of male sexual development (English)

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14 August 2017

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14 August 2017

Peter Koopman

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14 August 2017

publication date

11 July 2006

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14 August 2017

published in

Nature Reviews Genetics

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

620-631

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A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

14 August 2017

cites work

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A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

21 January 2018

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The LIM homeobox gene Lhx9 is essential for mouse gonad formation

21 January 2018

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A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans

21 January 2018

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The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans

21 January 2018

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Sex determination: a 'window' of DAX1 activity

21 January 2018

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Genetic evidence equating SRY and the testis-determining factor

21 January 2018

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A human XY female with a frame shift mutation in the candidate testis-determining gene SRY.

21 January 2018

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Male development of chromosomally female mice transgenic for Sry.

21 January 2018

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Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination

21 January 2018

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Testis determination requires insulin receptor family function in mice

21 January 2018

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Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

21 January 2018

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Reverse transcription-polymerase chain reaction analysis of genes involved in gonadal differentiation in pigs

21 January 2018

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Widespread expression of the testis–determining gene SRY in a marsupial

21 January 2018

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Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.

21 January 2018

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Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads

21 January 2018

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A familial mutation in the testis-determining gene SRY shared by both sexes

21 January 2018

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DNA Binding Activity of Recombinant SRY from Normal Males and XY Females

21 January 2018

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Two new novel point mutations localized upstream and downstream of the HMG box region of the SRY gene in three Indian 46,XY females with sex reversal and gonadal tumour formation

21 January 2018

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Three new novel point mutations localized within and downstream of high-mobility group-box region in SRY gene in three Indian females with Turner syndrome

21 January 2018

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A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development

21 January 2018

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Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation

21 January 2018

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Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

21 January 2018

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SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro

21 January 2018

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Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

21 January 2018

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Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9

21 January 2018

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Sox9 induces testis development in XX transgenic mice

21 January 2018

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Autosomal XX sex reversal caused by duplication of SOX9.

21 January 2018

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A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse

21 January 2018

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Functional analysis of Sox8 and Sox9 during sex determination in the mouse

21 January 2018

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Homozygous inactivation of Sox9 causes complete XY sex reversal in mice

21 January 2018

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Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad.

21 January 2018

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21 January 2018

The battle of the sexes

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Mammalian sex determination: a molecular drama

21 January 2018

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Migration of mesonephric cells into the mammalian gonad depends on Sry.

21 January 2018

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Male-specific cell migration into the developing gonad.

21 January 2018

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Pleiotropic activity of hepatocyte growth factor during embryonic mouse testis development.

21 January 2018

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Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling

21 January 2018

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Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis.

21 January 2018

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Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules

21 January 2018

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Sertoli cell signaling by Desert hedgehog regulates the male germline

21 January 2018

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A developmental study of the Desert hedgehog-null mouse testis

21 January 2018

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A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis

21 January 2018

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Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis

21 January 2018

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Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad

21 January 2018

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Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression

21 January 2018

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Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad

21 January 2018

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Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

21 January 2018

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Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation

21 January 2018

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ATRX and sex differentiation

21 January 2018

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Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad

21 January 2018

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Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice

21 January 2018

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IFITM/Mil/Fragilis Family Proteins IFITM1 and IFITM3 Play Distinct Roles in Mouse Primordial Germ Cell Homing and Repulsion

21 January 2018

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The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival

21 January 2018

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Entry of Mouse Embryonic Germ Cells into Meiosis

21 January 2018

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Germ and somatic cell lineages in the developing gonad

21 January 2018

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Retinoic acid regulates sex-specific timing of meiotic initiation in mice

21 January 2018

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Retinoid signaling determines germ cell fate in mice

21 January 2018

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A cytological and cytoskeletal comparison of Sertoli cells without germ cell and those with germ cells using the W/WV mutant mouse

21 January 2018

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Insulin-like 3 signalling in testicular descent

21 January 2018

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Cryptorchidism: an indicator of testicular dysgenesis?

21 January 2018

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The molecular basis of cryptorchidism.

21 January 2018

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Molecular genetics of the persistent müllerian duct syndrome: a study of 19 families.

21 January 2018

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Persistent Mullerian duct syndrome caused by both a 27-bp deletion and a novel splice mutation in the MIS type II receptor gene.

21 January 2018

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5 The in Vivo Roles of Müllerian-inhibiting Substance

21 January 2018

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Expression of bone morphogenetic protein 7 in murine epididymis is developmentally regulated.

21 January 2018

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Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity

21 January 2018

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The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation

21 January 2018

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The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis

21 January 2018

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Defective postnatal development of the male reproductive tract in LGR4 knockout mice

21 January 2018

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Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice

21 January 2018

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CFTR mutations and polymorphisms in male infertility

21 January 2018

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Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia.

21 January 2018

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Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development

21 January 2018

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Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome

21 January 2018

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The pathophysiology of HOX genes and their role in cancer.

21 January 2018

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Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model

21 January 2018

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Molecular epidemiology of hypospadias: review of genetic and environmental risk factors

21 January 2018

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The endocrinology and developmental biology of the prostate

21 January 2018

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Ductal budding and branching patterns in the developing prostate.

21 January 2018

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Hormonal, cellular, and molecular control of prostatic development

21 January 2018

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SAGE reveals expression of Wnt signalling pathway members during mouse prostate development

21 January 2018

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Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation

21 January 2018

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21 January 2018

The human SRY transcript

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Transcription of the Y chromosomal gene, Sry, in adult mouse brain

21 January 2018

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Developmental profile of Sry transcripts in mouse brain.

21 January 2018

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Direct regulation of adult brain function by the male-specific factor SRY

21 January 2018

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WT1--more than a transcription factor?

21 January 2018

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Spatially dynamic expression ofSry in mouse genital ridges

31 March 2020

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Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal

31 March 2020

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Sex reversal caused by Mus musculus domesticus Y chromosomes linked to variant expression of the testis-determining gene Sry

31 March 2020

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[Gonadal dysgenesis: modern concepts]

31 March 2020

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Sex-reversing mutations affect the architecture of SRY-DNA complexes

31 March 2020

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Two new point mutations of the SRY gene identified in two Italian 46,XY females with gonadal dysgenesis

31 March 2020

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Expression and action of neurotropin-3 and nerve growth factor in embryonic and early postnatal rat testis development

31 March 2020

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Kinetics of gametogenesis. I. Comparative histological and autoradiographic studies of oocytes and transitional prospermatogonia during oogenesis and prespermatogenesis

31 March 2020

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Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis

31 March 2020

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The relaxin gene-knockout mouse: a model of progressive fibrosis

31 March 2020

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The adrenogenital syndrome

31 March 2020

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A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits.

31 March 2020

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The Y-chromosomal genes SRY and ZFY are transcribed in adult human brain

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1903

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14 August 2017

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