Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants (Q36535990)

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scientific article published on 27 July 2007

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English	Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants	scientific article published on 27 July 2007

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instance of

scholarly article

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PMC publication ID

2291266

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14 August 2017

title

Time-dependent inhibition of human drug metabolizing cytochromes P450 by tricyclic antidepressants (English)

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

author name string

Thomas M Polasek

series ordinal

1

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

John O Miners

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2

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

language of work or name

English

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publication date

27 July 2007

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

published in

British Journal of Clinical Pharmacology

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

volume

65

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

issue

1

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

page(s)

87-97

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Europe PubMed Central

PMC publication ID

2291266

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14 August 2017

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30 September 2017

Metabolism of tricyclic antidepressants

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21 September 2018

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21 September 2018

Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoin

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21 September 2018

Inhibition and metabolite complexation of rat hepatic microsomal cytochrome p450 by tricyclic antidepressants

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21 September 2018

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12 December 2020

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Inhibition of microsomal cytochromes P450 in rat liver by the tricyclic antidepressant drug desipramine and its primary oxidized metabolites

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Dose-dependent elimination of propranolol and its major metabolites in humans

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Nonlinear pharmacokinetics of unbound propranolol after oral administration

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Dextromethorphan and mephenytoin phenotyping of patients treated with thioridazine or amitriptyline

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

based on heuristic

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Improved reliability of the rapid microtiter plate assay using recombinant enzyme in predicting CYP2D6 inhibition in human liver microsomes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

based on heuristic

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Common multiple interactions of tricyclic anti-depressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

based on heuristic

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Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli

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12 December 2020

based on heuristic

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The effect of cimetidine on dextromethorphan O-demethylase activity of human liver microsomes and recombinant CYP2D6

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

based on heuristic

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Metabolite intermediate complexation of microsomal cytochrome P450 2C11 in male rat liver by nortriptyline

1 reference

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https://pubmed.ncbi.nlm.nih.gov/17662092

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12 December 2020

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Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms

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Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs

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Identifiers

DOI

10.1111/J.1365-2125.2007.02964.X

1 reference

stated in

Europe PubMed Central

PMC publication ID

2291266

retrieved

14 August 2017

PMC publication ID

2291266

1 reference

stated in

Europe PubMed Central

PMC publication ID

2291266

retrieved

14 August 2017

PubMed publication ID

17662092

1 reference

stated in

Europe PubMed Central

PMC publication ID

2291266

retrieved

14 August 2017

ResearchGate publication ID

6177220

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