Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition (Q36525662)

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scientific article published on 28 January 2013

Language	Label	Description	Also known as
English	Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition	scientific article published on 28 January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

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author name string

Alice Ban Ke

1

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Europe PubMed Central

PMC publication ID

14 August 2017

Sara Eyal

2

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Europe PubMed Central

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14 August 2017

Francisco S Chung

3

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Europe PubMed Central

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14 August 2017

Jeanne M Link

4

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Europe PubMed Central

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14 August 2017

David A Mankoff

5

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Europe PubMed Central

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14 August 2017

Mark Muzi

6

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14 August 2017

Jashvant D Unadkat

7

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14 August 2017

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publication date

28 January 2013

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14 August 2017

The Journal of Nuclear Medicine

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14 August 2017

54

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14 August 2017

3

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14 August 2017

437-446

1 reference

Europe PubMed Central

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14 August 2017

Pgp-mediated interaction between (R)-[11C]verapamil and tariquidar at the human blood-brain barrier: a comparison with rat data

1 reference

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Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion during early implantation in the macaque uterus.

1 reference

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The role of the placenta in fetal exposure to xenobiotics: importance of membrane transporters and human models for transfer studies.

1 reference

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30 September 2017

Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography

1 reference

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30 September 2017

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide

1 reference

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30 September 2017

Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate

1 reference

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30 September 2017

A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET

1 reference

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Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

1 reference

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30 September 2017

Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans

1 reference

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30 September 2017

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate

1 reference

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30 September 2017

Drug interactions at the blood-brain barrier: fact or fantasy?

1 reference

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30 September 2017

P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys

1 reference

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30 September 2017

Rapid solid-phase extraction method to quantify [(11)C]-verapamil, and its [(11)C]-metabolites, in human and macaque plasma.

1 reference

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30 September 2017

Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function

1 reference

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30 September 2017

P-glycoprotein in the placenta: expression, localization, regulation and function.

1 reference

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30 September 2017

Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data

1 reference

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30 September 2017

Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents

1 reference

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Effects of anesthesia on functional activation of cerebral blood flow and metabolism

1 reference

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30 September 2017

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein

1 reference

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30 September 2017

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1 reference

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30 September 2017

Local cerebral blood flow in the conscious rat as measured with 14C-antipyrine, 14C-iodoantipyrine and 3H-nicotine

1 reference

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28 June 2018

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

1 reference

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21 September 2018

Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

1 reference

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21 September 2018

Model analysis of the concentration-dependent permeability of P-gp substrates

1 reference

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21 September 2018

In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier

1 reference

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Optimization algorithms and weighting factors for analysis of dynamic PET studies.

1 reference

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Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier

1 reference

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Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

1 reference

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21 September 2018

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23359659

12 December 2020

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Identifiers

10.2967/JNUMED.112.111732

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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