The many paths to p38 mitogen-activated protein kinase activation in the immune system (Q36518938)

14 August 2017

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title

The many paths to p38 mitogen-activated protein kinase activation in the immune system (English)

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14 August 2017

Jonathan D Ashwell

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14 August 2017

publication date

1 July 2006

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Nature Reviews Immunology

14 August 2017

published in

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

532-540

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Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine

14 August 2017

cites work

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The p38 signal transduction pathway: activation and function

31 March 2020

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

31 March 2020

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

31 March 2020

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

31 March 2020

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The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils

31 March 2020

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Crystal structure of p38 mitogen-activated protein kinase

31 March 2020

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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

31 March 2020

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The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

31 March 2020

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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

31 March 2020

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

31 March 2020

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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

31 March 2020

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The primary structure of p38 gamma: a new member of p38 group of MAP kinases

31 March 2020

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Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

31 March 2020

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Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling

31 March 2020

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

31 March 2020

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Feedback control of the protein kinase TAK1 by SAPK2a/p38

31 March 2020

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p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

31 March 2020

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

31 March 2020

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Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes

31 March 2020

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The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

31 March 2020

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p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

31 March 2020

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

31 March 2020

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Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study

31 March 2020

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Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans

31 March 2020

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Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia

31 March 2020

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P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia

31 March 2020

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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

31 March 2020

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Anti-TNF-alpha therapies: the next generation

31 March 2020

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Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent

31 March 2020

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Mechanism of p38 MAP kinase activation in vivo.

31 March 2020

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Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

31 March 2020

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Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis

31 March 2020

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Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

31 March 2020

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

31 March 2020

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p38 MAP kinase's emerging role as a tumor suppressor

31 March 2020

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Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

31 March 2020

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Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes

31 March 2020

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MAP-kinase signaling pathways in T cells

31 March 2020

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Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

31 March 2020

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

31 March 2020

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Functions of MAP kinases: insights from gene-targeting studies

31 March 2020

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Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

31 March 2020

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MAPK p38 alpha is dispensable for lymphocyte development and proliferation.

31 March 2020

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

31 March 2020

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p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

31 March 2020

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The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding

31 March 2020

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Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells

31 March 2020

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p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide

31 March 2020

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Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

31 March 2020

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Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages

31 March 2020

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The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells

31 March 2020

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Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death

31 March 2020

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Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells

31 March 2020

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

31 March 2020

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Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection

31 March 2020

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

31 March 2020

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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

31 March 2020

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TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1

31 March 2020

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Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

31 March 2020

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Activation of discoidin domain receptor 1 facilitates the maturation of human monocyte-derived dendritic cells through the TNF receptor associated factor 6/TGF-beta-activated protein kinase 1 binding protein 1 beta/p38 alpha mitogen-activated protei

31 March 2020

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p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection

31 March 2020

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Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation

31 March 2020

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Regulation of the maintenance of peripheral T-cell anergy by TAB1-1 mediated p38alpha activation

31 March 2020

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Deficiency of small GTPase Rac2 affects T cell activation

31 March 2020

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Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

31 March 2020

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A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

31 March 2020

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Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

31 March 2020

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Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding

31 March 2020

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GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells

31 March 2020

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Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells

31 March 2020

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GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.

31 March 2020

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Genomic instability in Gadd45a-deficient mice

31 March 2020

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Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a

31 March 2020

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Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.

31 March 2020

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The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

31 March 2020

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Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

31 March 2020

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

31 March 2020

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Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

31 March 2020

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Activating p38 MAPK: new tricks for an old kinase.

31 March 2020

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Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

31 March 2020

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Protein modification: docking sites for kinases

31 March 2020

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Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residues

31 March 2020

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A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1.

31 March 2020

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Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1865

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14 August 2017

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