Toxic effects of chemicals: difficulties in extrapolating data from animals to man. (Q36490216)

14 August 2017

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title

Toxic effects of chemicals: difficulties in extrapolating data from animals to man. (English)

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14 August 2017

Garattini S

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14 August 2017

language of work or name

English

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publication date

1 January 1985

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Critical Reviews in Toxicology

14 August 2017

published in

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

1-29

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Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Altered theophylline pharmacokinetics during acute respiratory viral illness

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

The renal toxicity of cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Specificity of Cerebral Amino Acid Transport: A Kinetic Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Clinical pharmacokinetics of cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Complex tight junctions of epithelial and of endothelial cells in early foetal brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Blood-brain barrier to albumin in embryonic new born and adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Accumulation of glutamic acid in the arcuate nucleus of the hypothalamus of the infant mouse followng subcutaneous administration of monosodium glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Glutamate accumulation in infant mouse hypothalamus: Influence of temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

3H-reserpine persistently bound "in vivo" to rat brain subcellular components: limited removal by peanut oil extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Long-acting and short-acting benzodiazepines in the elderly: kinetic differences and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Pharmacokinetics of VP16-213 in Lewis lung carcinoma bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Studies on brain lesions after administration of monosodium L-glutamate to mice. II. Absence of brain damage following administration of monosodium L-glutamate in the diet

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Benzodiazepines: clinical pharmacology and therapeutic use.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Notes on xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Benzodiazepines: relationship between pharmacological activity in the rat and in vivo receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Kinetics and metabolism of clobazam in animals and man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

D-Fenfluramine and D-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Distinct α-noradrenergic receptors differentiated by binding and physiological relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Distribution, metabolism, and irreversible binding of hexamethylmelamine in mice bearing ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Further studies on brain concentrations of amphetamine and its metabolites in strains of mice showing different sensitivity to pharmacological effects of amphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

A genetic analysis of the hyperthermic response to d-amphetamine in two inbred strains of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Studies with amphetamine in hyper- and hypothyroid rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Pharmacokinetic approach to in vitro testing of ovarian cancer cell sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Multiplicity of Liver Drug Metabolizing Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Tumoricidal responses in vitro of peritoneal macrophages from conventionally housed and germ-free nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Cytolytic and cytostatic activity on tumor cells of circulating human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Genotoxic and epigenetic carcinogens: their identification and significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Prostaglandins as Inhibitors of Human Platelet Aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Defective ristocetin and bovine factor VIII-induced platelet aggregation in normal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Characterization of arachidonic acid metabolic profiles in animal tissues by high-resolution gas chromatography-mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Distribution of prostaglandin biosynthetic pathways in several rat tissues. Formation of 6-ketoprostaglandin F1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Metabolism of prostaglandin endoperoxide by microsomes from human lung parenchyma and comparison with metabolites produced by pig, bovine, rat, mouse and guinea-pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Metabolism of prostaglandin endoperoxide in animal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Effect of aging on neurotransmitter receptor binding in rat and human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Effects of saccharin on primary humoral antibody production in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

In vitro effects of saccharin on cell-mediated host defence mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Intraperitoneal administration ofcorynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor-associated macrophages and NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

The metabolism of arachidonic acid by platelets in nephrotic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408448509041323

10.3109/10408448509041323

21 January 2018

Identifiers

DOI

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