Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. (Q36497621)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

review article

1 reference

title

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Genyuan Zhu

1 reference

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26 February 2020

language of work or name

1 reference

1 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cellular Physiology

26 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

230

1 reference

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26 February 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

1413-1420

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

26 February 2020

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30 September 2017

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Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

30 September 2017

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The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review

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30 September 2017

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AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers

30 September 2017

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GRP78 plays an essential role in adipogenesis and postnatal growth in mice

30 September 2017

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PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis

30 September 2017

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Mammary gland development

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Mutation of the BiP/GRP78 gene causes axon outgrowth and fasciculation defects in the thalamocortical connections of the mammalian forebrain

30 September 2017

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Cell intrinsic role of COX-2 in pancreatic cancer development

30 September 2017

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Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.

30 September 2017

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Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

30 September 2017

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The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

30 September 2017

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The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

30 September 2017

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Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks

30 September 2017

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Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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The Endoplasmic Reticulum Chaperone Protein GRP94 Is Required for Maintaining Hematopoietic Stem Cell Interactions with the Adult Bone Marrow Niche

30 September 2017

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30 September 2017

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A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis

30 September 2017

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Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

30 September 2017

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Liver stem/progenitor cells: their characteristics and regulatory mechanisms

30 September 2017

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Re-Examination of CD91 Function in GRP94 (Glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-Presentation

30 September 2017

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Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis

30 September 2017

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Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling

30 September 2017

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30 September 2017

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gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

30 September 2017

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Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors

30 September 2017

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Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

30 September 2017

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Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

30 September 2017

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Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

30 September 2017

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30 September 2017

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The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis

30 September 2017

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Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

30 September 2017

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Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling

30 September 2017

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30 September 2017

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Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism

30 September 2017

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Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

30 September 2017

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PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

30 September 2017

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Stem cells, self-renewal, and differentiation in the intestinal epithelium

30 September 2017

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

30 September 2017

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Regulation of hepatic lipogenesis by the transcription factor XBP1

30 September 2017

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The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

30 September 2017

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Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin

30 September 2017

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GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth

30 September 2017

1 reference

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Altered quality control in the endoplasmic reticulum causes cortical dysplasia in knock-in mice expressing a mutant BiP.

30 September 2017

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The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

30 September 2017

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The transcription factor XBP-1 is essential for the development and survival of dendritic cells

30 September 2017

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GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion

30 September 2017

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Signal integration in the endoplasmic reticulum unfolded protein response

30 September 2017

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ER chaperones in mammalian development and human diseases

30 September 2017

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GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

30 September 2017

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Adipocytes as regulators of energy balance and glucose homeostasis

30 September 2017

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Adipocyte differentiation from the inside out

30 September 2017

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GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

30 September 2017

1 reference

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BiP regulates autoimmune inflammation and tissue damage

30 September 2017

1 reference

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ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

30 September 2017

1 reference

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Role of cholesterol and lipid organization in disease

30 September 2017

1 reference

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The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone

30 September 2017

1 reference

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Roles of heat shock protein gp96 in the ER quality control: redundant or unique function?

30 September 2017

1 reference

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The mammalian unfolded protein response

30 September 2017

1 reference

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Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

30 September 2017

1 reference

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Modulation of neurodegeneration by molecular chaperones

30 September 2017

1 reference

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The role of the unfolded protein response in tumour development: friend or foe?

30 September 2017

1 reference

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Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

30 September 2017

1 reference

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

30 September 2017

1 reference

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A trip to the ER: coping with stress

30 September 2017

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

The glucose-regulated proteins: stress induction and clinical applications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Plasma cell differentiation requires the transcription factor XBP-1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Rabbit cardiac and skeletal myocytes differ in constitutive and inducible expression of the glucose-regulated protein GRP94

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Synthesis, intracellular transport and discharge of exportable proteins in the pancreatic acinar cell and other cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

ER stress induces epithelial differentiation in the mouse oesophagus.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4725317

21 September 2018

Reply: To PMID 24027047.

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FJCP.24923

Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FJCP.24923

21 January 2018

Identifiers

DOI

10.1002/JCP.24923

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

25546813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25546813%20AND%20SRC:MED&resulttype=core&format=json