SERCA2a in heart failure: role and therapeutic prospects (Q36476041)

14 August 2017

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title

SERCA2a in heart failure: role and therapeutic prospects (English)

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14 August 2017

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Davide Gianni

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14 August 2017

Joachim Chan

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14 August 2017

Judith K Gwathmey

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14 August 2017

Federica del Monte

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14 August 2017

Roger J Hajjar

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14 August 2017

publication date

1 December 2005

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Journal of Bioenergetics and Biomembranes

14 August 2017

published in

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

375-380

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Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a

14 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Relation between steady-state force and intracellular [Ca2+] in intact human myocardium. Index of myofibrillar responsiveness to Ca2+.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Phospholamban: a prominent regulator of myocardial contractility

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Tight control of exogenous SERCA expression is required to obtain acceleration of calcium transients with minimal cytotoxic effects in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-005-9474-Z

Functional consequences of alterations to amino acids located in the catalytic center (isoleucine 348 to threonine 357) and nucleotide-binding domain of the Ca2+-ATPase of sarcoplasmic reticulum

21 January 2018

1 reference

12 December 2020

Targeting phospholamban by gene transfer in human heart failure

1 reference

12 December 2020

Functional consequences of glutamate, aspartate, glutamine, and asparagine mutations in the stalk sector of the Ca2+-ATPase of sarcoplasmic reticulum

1 reference

12 December 2020

Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPase

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12 December 2020

Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane

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12 December 2020

Altered calcium handling in experimental pressure-overload hypertrophy in the ferret

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12 December 2020

Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure

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12 December 2020

Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes

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12 December 2020

Structural basis of ion pumping by Ca(2+)-ATPase of sarcoplasmic reticulum.

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12 December 2020

Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure

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12 December 2020

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure

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12 December 2020

Probing nucleotide-binding effects on backbone dynamics and folding of the nucleotide-binding domain of the sarcoplasmic/endoplasmic-reticulum Ca2+-ATPase.

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12 December 2020

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution

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12 December 2020

Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.

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12 December 2020

Identification of a new SERCA2 splice variant regulated during monocytic differentiation

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12 December 2020

Pathophysiology of cardiomyopathies: Part II. Drug-induced and other interventions

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12 December 2020

Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes.

1 reference

12 December 2020

Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

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12 December 2020

Detailed characterization of the cooperative mechanism of Ca(2+) binding and catalytic activation in the Ca(2+) transport (SERCA) ATPase

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12 December 2020

Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes

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12 December 2020

Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum

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12 December 2020

Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure

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12 December 2020

Mutations in the gene-encoding SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with Brody disease

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12 December 2020

Pathophysiology of chronic heart failure

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12 December 2020

Functional and structural roles of critical amino acids within the"N", "P", and "A" domains of the Ca2+ ATPase (SERCA) headpiece

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12 December 2020

Relationship of abnormal intracellular calcium mobilisation to myocyte hypertrophy in human ventricular myocardium

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12 December 2020

Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transfer

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12 December 2020

Functional consequences of mutations of conserved amino acids in the beta-strand domain of the Ca2(+)-ATPase of sarcoplasmic reticulum

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12 December 2020

Deletion of NH2 − and COOH-terminal sequences destroys function of the Ca2+ ATPase of rabbit fast-twitch skeletal muscle sarcoplasmic reticulum

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12 December 2020

Phosphorylation of inhibitory subunit of troponin and phospholamban in rat cardiomyocytes: modulation by exposure of cardiomyocytes to hydroxyl radicals and sulfhydryl group reagents

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12 December 2020

Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca(2+)-ATPase of sarcoplasmic reticulum.

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12 December 2020

Developmental changes of Ca(2+) handling in mouse ventricular cells from early embryo to adulthood

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12 December 2020

Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum

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12 December 2020

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure

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12 December 2020

Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure

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12 December 2020

Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ?

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12 December 2020

Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum

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12 December 2020

Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes

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12 December 2020

Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle

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12 December 2020

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

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12 December 2020

Mutational analysis of the role of Glu309 in the sarcoplasmic reticulum Ca(2+)-ATPase of frog skeletal muscle

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12 December 2020

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12 December 2020

Functional consequences of alterations to hydrophobic amino acids located at the M4S4 boundary of the Ca(2+)-ATPase of sarcoplasmic reticulum

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12 December 2020

The mutation of Pro789 to Leu reduces the activity of the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) and is associated with Brody disease

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12 December 2020

Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo

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12 December 2020

Integrated Ca2+ management in cardiac myocytes

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12 December 2020

Defects in calcium control

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12 December 2020

Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference?

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12 December 2020

Regulation of Sarco(endo)plasmic Reticulum Ca2+ Adenosine Triphosphatase by Phospholamban and Sarcolipin Implication for Cardiac Hypertrophy and Failure

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12 December 2020

Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function

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12 December 2020

Targeting calcium cycling proteins in heart failure through gene transfer

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12 December 2020

Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase

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12 December 2020

Functional consequences of proline mutations in the cytoplasmic and transmembrane sectors of the Ca2(+)-ATPase of sarcoplasmic reticulum

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12 December 2020

Altered intracellular Ca2+ handling in heart failure

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12 December 2020

The structure of the Ca2+-ATPase of sarcoplasmic reticulum

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12 December 2020

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca 2+ Uptake and Ca 2+ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

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12 December 2020

Functional consequences of alterations to Glu309, Glu771, and Asp800 in the Ca(2+)-ATPase of sarcoplasmic reticulum

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12 December 2020

Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene

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12 December 2020

Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

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12 December 2020

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1

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12 December 2020

10.1007/S10863-005-9474-Z

Identifiers

DOI

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14 August 2017

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