Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models. (Q36446451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23226094%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models (English)

1 reference

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20 February 2020

1 reference

1 reference

head and neck carcinoma

1 reference

1 reference

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20 February 2020

Jennifer Rubin Grandis

object named as

Jennifer R Grandis

1 reference

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20 February 2020

Andre Cassell

1 reference

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20 February 2020

Maria L Freilino

1 reference

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20 February 2020

Jessica Lee

1 reference

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20 February 2020

Sharon Barr

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20 February 2020

Lin Wang

1 reference

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20 February 2020

Mary C Panahandeh

1 reference

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20 February 2020

publication date

1 November 2012

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20 February 2020

1 reference

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20 February 2020

volume

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20 February 2020

issue

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20 February 2020

page(s)

1005-1014

1 reference

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describes a project that uses

20 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3514742/fullTextXML

inferred from PubMed Central ID database lookup

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Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma

30 September 2017

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Concurrent cetuximab, cisplatin, and radiation for squamous cell carcinoma of the head and neck in vitro.

30 September 2017

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

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A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.

30 September 2017

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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

30 September 2017

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

30 September 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

30 September 2017

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

30 September 2017

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Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck

30 September 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

30 September 2017

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

30 September 2017

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

30 September 2017

1 reference

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A new human cell line (FaDu) from a hypopharyngeal carcinoma.

30 September 2017

1 reference

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Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment.

28 June 2018

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Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

28 June 2018

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Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model

21 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514742

Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.

21 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514742

Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514742

Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514742

Open-Label, Uncontrolled, Multicenter Phase II Study to Evaluate the Efficacy and Toxicity of Cetuximab As a Single Agent in Patients With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck Who Failed to Respond to Platinum-Base

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3514742

Human Squamous Cell Carcinoma: Establishment and Characterization of New Permanent Cell Lines

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23226094

12 December 2020

inferred from PubMed ID database lookup

Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23226094

12 December 2020

inferred from PubMed ID database lookup

Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23226094

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1593/NEO.121212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23226094%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23226094%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

23226094

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23226094%20AND%20SRC:MED&resulttype=core&format=json