Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients (Q36390262)

13 August 2017

Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients (English)

1 reference

13 August 2017

Jason M White

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13 August 2017

Janet K Coller

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13 August 2017

Jennifer R Michalakas

1 reference

13 August 2017

Heather M James

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13 August 2017

Aaron L Farquharson

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13 August 2017

Joel Colvill

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13 August 2017

Andrew A Somogyi

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13 August 2017

language of work or name

English

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publication date

1 November 2012

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British Journal of Clinical Pharmacology

13 August 2017

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13 August 2017

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13 August 2017

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13 August 2017

835-841

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Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Acute Pain Management in Opioid-Tolerant Patients: A Growing Challenge

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Predicting drug-drug interactions: an FDA perspective

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Role of active metabolites in the use of opioids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subje

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Acute pain management for patients receiving maintenance methadone or buprenorphine therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Clinical pharmacology of tramadol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Polymorphic CYP2D6 mediates O -demethylation of the opioid analgesic tramadol

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

The metabolism of tramadol by human liver microsomes

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

Buprenorphine versus methadone maintenance: a cost-effectiveness analysis

28 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Pharmacokinetics and pharmacodynamics of multiple sublingual buprenorphine tablets in dose-escalation trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Comparison of cerebral pharmacokinetics of buprenorphine and norbuprenorphine in an in vivo sheep model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Confidence intervals for an effect size measure based on the Mann-Whitney statistic. Part 1: general issues and tail-area-based methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Confidence intervals for an effect size measure based on the Mann-Whitney statistic. Part 2: asymptotic methods and evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Impact of CYP2D6 genotype on postoperative tramadol analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Assessment of agonist and antagonist effects of tramadol in opioid-dependent humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2012.04256.X

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495148

A new simple diagnostic assay for the identification of the major CYP2D6 genotypes by DNA sequencing analysis

21 September 2018

1 reference

12 December 2020

Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes

1 reference

12 December 2020

High-performance liquid chromatographic assay for the simultaneous determination of tramadol and its metabolites in microsomal fractions of human liver

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

10.1111/J.1365-2125.2012.04256.X

Identifiers

DOI

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

22369095

1 reference