Statins and bone metabolism (Q36395695)

13 August 2017

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title

Statins and bone metabolism (English)

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13 August 2017

Horiuchi N

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13 August 2017

Maeda T

series ordinal

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13 August 2017

publication date

1 March 2006

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13 August 2017

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

85-101

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Simvastatin promotes osteogenesis around titanium implants

13 August 2017

cites work

1 reference

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HMG CoA reductase inhibitors and the skeleton: a comprehensive review

21 January 2018

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Bone marrow stromal stem cells: nature, biology, and potential applications

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statin effects beyond lipid lowering--are they clinically relevant?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Cardiovascular disease and osteoporosis: is there a link between lipids and bone?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Protein prenyltransferases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Changes in endothelium-dependent vasodilatation and alpha-adrenergic responses in resistance vessels during the menstrual cycle in healthy women

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Estrogens, bone loss and preservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

New insights into the pharmacodynamic and pharmacokinetic properties of statins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Cholesterol metabolism in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Functional hierarchy between two OSE2 elements in the control of osteocalcin gene expression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Natural statins and stroke risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The function of adipocytes in the bone marrow stroma: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Prognostic value of coronary vascular endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Cbfa1 isoforms exert functional differences in osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Withdrawal of statins increases event rates in patients with acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Structural mechanism for statin inhibition of HMG-CoA reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Estrogen deposits extra mineral into bones of female rats in puberty, but simultaneously seems to suppress the responsiveness of female skeleton to mechanical loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Atorvastatin enhances bone density in ovariectomized rats given 17beta-estradiol or human parathyroid hormone(1-34).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Bone mineral density of the mandible in ovariectomized rats: analyses using dual energy X-ray absorptiometry and peripheral quantitative computed tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Current concepts in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Invited review of a workshop: anabolic hormones in bone: basic research and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Current perspectives on statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

HMG-CoA reductase inhibitors and the risk of fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statins and their potential for osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Stimulation of bone formation in vitro and in rodents by statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The benefits of estrogen replacement therapy on oral health. The Leisure World cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Compactin enhances osteogenesis in murine embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Could atherosclerosis originate from defective smooth muscle cell death (apoptosis)?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The pathogenesis of atherosclerosis: a perspective for the 1990s

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Bone morphogenetic proteins: from basic studies to clinical approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Use of statins and risk of fractures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Recent advances in multifactorial regulation of vascular calcification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The evolving role of statins in the management of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The pleiotropic effects of HMG-CoA reductase inhibitors: their role in osteoporosis and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Effects of 1-year treatment with fluvastatin or pravastatin on bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Simvastatin reduces graft vessel disease and mortality after heart transplantation: a four-year randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Endothelium-dependent effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Osteoporosis: a risk factor in periodontal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Mechanical strain induces collagenase-3 (MMP-13) expression in MC3T3-E1 osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Skeletal Effects of Statins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

Statin Use, Bone Mineral Density, and Fracture Risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1601-0825.2005.01172.X

10.1111/J.1601-0825.2005.01172.X

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference