A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease (Q36385926)

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English	A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Alzheimer's disease

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author name string

Angela Fortner McKoy

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jermont Chen

2

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Europe PubMed Central

PMC publication ID

13 August 2017

Trudi Schupbach

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Michael H Hecht

4

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Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

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publication date

19 September 2012

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Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

13 August 2017

287

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Europe PubMed Central

PMC publication ID

13 August 2017

46

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

38992-39000

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

1 reference

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Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models

1 reference

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Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor

1 reference

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Alzheimer's disease: strategies for disease modification

1 reference

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30 September 2017

Protective effect of a triazine-derivative (AA3E2) on beta-amyloid-induced damages in SK-N-MC cells

1 reference

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30 September 2017

Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells

1 reference

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30 September 2017

Structural classification of toxic amyloid oligomers

1 reference

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Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

1 reference

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

1 reference

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ChemBank: a small-molecule screening and cheminformatics resource database

1 reference

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30 September 2017

Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway

1 reference

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30 September 2017

A beta oligomers - a decade of discovery

1 reference

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30 September 2017

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide

1 reference

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30 September 2017

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

1 reference

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30 September 2017

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

1 reference

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30 September 2017

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

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30 September 2017

Amyloid accomplices and enforcers

1 reference

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The importance of neuritic plaques and tangles to the development and evolution of AD

1 reference

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Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

1 reference

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

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Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

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Deciphering the genetic basis of Alzheimer's disease

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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30 September 2017

The amyloid-beta peptide and its role in Alzheimer's disease

1 reference

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30 September 2017

Alzheimer's disease: genes, proteins, and therapy

1 reference

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30 September 2017

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands.

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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30 September 2017

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

1 reference

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Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution

1 reference

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Inhibition of H2O2-induced neuroblastoma cell cytotoxicity by a triazine derivative, AA3E2.

1 reference

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Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

1 reference

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A Drosophila model of Alzheimer's disease

1 reference

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Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study.

1 reference

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Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt.

1 reference

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Rapid protein-folding assay using green fluorescent protein

1 reference

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21 October 2018

Identifiers

10.1074/JBC.M112.348037

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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