Nitrones as therapeutics in age-related diseases (Q36379608)

13 August 2017

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title

Nitrones as therapeutics in age-related diseases (English)

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13 August 2017

Robert A Floyd

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13 August 2017

publication date

1 February 2006

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13 August 2017

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13 August 2017

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13 August 2017

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13 August 2017

page(s)

51-57

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Specific interaction of methionine adenosyltransferase with free radicals.

13 August 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain

21 January 2018

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Alterations in the intrauterine environment by glucocorticoids modifies the developmental programme of the auditory system

21 January 2018

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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Acrylonitrile potentiates noise-induced hearing loss in rat.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Cochlear protection from carbon monoxide exposure by free radical blockers in the guinea pig.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Antioxidants, oxidative stress, and degenerative neurological disorders

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitrones, their value as therapeutics and probes to understand aging

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Free radical trapping as a therapeutic approach to neuroprotection in stroke: experimental and clinical studies with NXY-059 and free radical scavengers

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Tolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Tolerability of NXY-059 at higher target concentrations in patients with acute stroke

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Effects of phenyl N‐tert‐butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline‐deficient, L‐amino acid‐defined diet

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Methionine adenosyltransferase S-nitrosylation is regulated by the basic and acidic amino acids surrounding the target thiol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitric oxide suppression triggers apoptosis through the FKHRL1 (FOXO3A)/ROCK kinase pathway in human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Protective effects of phenyl-N-tert-butylnitrone on the potentiation of noise-induced hearing loss by carbon monoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Nitric oxide inactivates rat hepatic methionine adenosyltransferase In vivo by S-nitrosylation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Pharmacokinetics in renally impaired subjects of NXY-059, a nitrone-based, free-radical trapping agent developed for the treatment of acute stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00189.X

10.1111/J.1474-9726.2006.00189.X

21 January 2018

Identifiers

DOI

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13 August 2017

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