Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice (Q36361909)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8315397%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

title

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice (English)

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29 October 2019

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29 October 2019

M J Rapoport

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29 October 2019

A Jaramillo

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29 October 2019

D Zipris

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29 October 2019

D V Serreze

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29 October 2019

E H Leiter

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29 October 2019

P Cyopick

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29 October 2019

J S Danska

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29 October 2019

T L Delovitch

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29 October 2019

language of work or name

English

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publication date

1 July 1993

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Journal of Experimental Medicine

29 October 2019

published in

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29 October 2019

volume

178

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issue

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29 October 2019

page(s)

87-99

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Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation

29 October 2019

cites work

1 reference

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In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen

30 September 2017

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Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

30 September 2017

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Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen

30 September 2017

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30 September 2017

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Identification of a monoclonal antibody specific for a murine T3 polypeptide

30 September 2017

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Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice

30 September 2017

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The genetics of diabetes susceptibility in mice

30 September 2017

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

30 September 2017

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

30 September 2017

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Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

30 September 2017

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Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities

30 September 2017

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In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

30 September 2017

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Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.

30 September 2017

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Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

30 September 2017

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The role of the T cell receptor in positive and negative selection of developing T cells

30 September 2017

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T cell antigen receptor activation pathways: The tyrosine kinase connection

30 September 2017

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Subsets of CD4+T Cells and their Roles in the Induction and Prevention of Autoimmunity

30 September 2017

1 reference

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Th0 Cells in the Thymus: The Question of T-Helper Lineages

30 September 2017

1 reference

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Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development

30 September 2017

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Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

30 September 2017

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IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells

28 June 2018

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IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli

28 June 2018

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Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis

28 June 2018

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28 June 2018

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Interleukin 2 deficiency is a common feature of autoimmune mice

28 June 2018

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12 December 2020

Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus

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12 December 2020

Preparation and characterization of a "pan-reactive" rabbit anti-mouse T-cell receptor antiserum

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12 December 2020

Recombinant interleukin 4 promotes the growth of human T cells

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12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

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12 December 2020

Promotion of human T lymphocyte proliferation by IL-4

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12 December 2020

Immunostimulation circumvents diabetes in NOD/Lt mice

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12 December 2020

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones

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12 December 2020

Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance

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12 December 2020

Autoimmune diseases: the failure of self tolerance

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12 December 2020

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production

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12 December 2020

Impaired mitogen-induced expression of high-affinity interleukin 2 receptors on spleen cells from NOD/Shi/Kbe mice

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12 December 2020

A bidirectional regulatory network involving IL 2 and IL 4 in the alternative CD2 pathway of T cell activation

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12 December 2020

Altered Thymic and Peripheral T-Lymphocyte Repertoire Preceding Onset of Diabetes in NOD Mice

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12 December 2020

T-Lymphocyte Changes Linked to Autoantibodies: Association of Insulin Autoantibodies With CD4+CD45R+ Lymphocyte Subpopulation in Prediabetic Subjects

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12 December 2020

Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma

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12 December 2020

Interplay between IL-2 and IL-4 in human thymocyte differentiation: antagonism or agonism

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12 December 2020

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation

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12 December 2020

Clonal anergy blocks the response to IL-4, as well as the production of IL-2, in dual-producing T helper cell clones

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12 December 2020

Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes

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12 December 2020

Identifiers

DOI

10.1084/JEM.178.1.87

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8315397%20AND%20SRC:MED&resulttype=core&format=json

29 October 2019

1 reference

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29 October 2019

PubMed publication ID

8315397

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8315397%20AND%20SRC:MED&resulttype=core&format=json