Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells (Q36305532)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942986%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells (English)

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13 February 2020

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13 February 2020

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13 February 2020

D Haridas

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13 February 2020

M E Wagener

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13 February 2020

M Song

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13 February 2020

A D Kirk

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13 February 2020

M L Ford

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13 February 2020

language of work or name

English

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publication date

22 September 2011

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American Journal of Transplantation

13 February 2020

published in

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13 February 2020

volume

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13 February 2020

issue

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13 February 2020

page(s)

69-80

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LFA-1 antagonism inhibits early infiltration of endogenous memory CD8 T cells into cardiac allografts and donor-reactive T cell priming

13 February 2020

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Costimulation blockade: towards clinical application

30 September 2017

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Integrin modulation and signaling in leukocyte adhesion and migration

30 September 2017

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Transplant tolerance through costimulation blockade--are we there yet?

30 September 2017

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The impact of memory T cells on rejection and the induction of tolerance.

30 September 2017

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A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression

30 September 2017

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Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords?

30 September 2017

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Quantitative PCR for detection of the OT-1 transgene

30 September 2017

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Integrins and T cell-mediated immunity

30 September 2017

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Heterologous immunity provides a potent barrier to transplantation tolerance

30 September 2017

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30 September 2017

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The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils.

30 September 2017

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Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection

30 September 2017

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Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.

30 September 2017

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Evaluation of a method for counting absolute numbers of cells with a flow cytometer

30 September 2017

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T cell receptor antagonist peptides induce positive selection

30 September 2017

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Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall

30 September 2017

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Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients

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22 September 2018

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22 September 2018

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Pretransplant cellular alloimmunity as assessed by a panel of reactive T cells assay correlates with acute renal graft rejection.

22 September 2018

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Perturbation of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 results in differential outcomes in cardiac vs islet allograft survival

22 September 2018

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Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection.

22 September 2018

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Pre-transplant IFN-gamma ELISPOTs are associated with post-transplant renal function in African American renal transplant recipients

22 September 2018

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The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice.

22 September 2018

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Cutting edge: rapid in vivo killing by memory CD8 T cells

22 September 2018

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Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients.

22 September 2018

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Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice.

22 September 2018

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Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen.

22 September 2018

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alpha4 integrin in islet allograft rejection

22 September 2018

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Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion

22 September 2018

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Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells

22 September 2018

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Costimulation blockade-induced cardiac allograft tolerance: inhibition of T cell expansion and accumulation of intragraft cD4(+)Foxp3(+) T cells

22 September 2018

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CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice

21 October 2018

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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

21 October 2018

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A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)

21 January 2018

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12 December 2020

Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection

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12 December 2020

Anti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-gamma or IL-4

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CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely

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CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways

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Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig

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Targeting LFA-1 Synergizes with CD40/CD40L Blockade for Suppression of Both CD4-Dependent and CD8-Dependent Rejection

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Development of a novel transgenic mouse for the study of interactions between CD4 and CD8 T cells during graft rejection

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Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

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The efficacy of LFA-1 and VLA-4 antibody treatment in rat vascularized cardiac allograft rejection

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Immunosuppression to cardiac allografts and soluble antigens by anti-vascular cellular adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies

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Prolongation of islet allograft survival with an antibody to vascular cell adhesion molecule 1

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Acceptance of primary skin graft after treatment with anti-intercellular adhesion molecule-1 and anti-leukocyte function-associated antigen-1 monoclonal antibodies in mice

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Effect of anti-intercellular adhesion molecule-1 and anti-leukocyte function associated antigen-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection

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Awareness of donor alloantigens in antiadhesion therapy induces antigen-specific unresponsiveness to islet allografts

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CD40-CD40L costimulation blockade induced the tolerogenic dendritic cells in mouse cardiac transplant

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12 December 2020

10.1111/J.1600-6143.2011.03762.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942986%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942986%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21942986

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21942986%20AND%20SRC:MED&resulttype=core&format=json