Human gene therapy comes of age. (Q36220668)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

review article

1 reference

title

Human gene therapy comes of age (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

Miller AD

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12 August 2017

language of work or name

English

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publication date

1 June 1992

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

volume

357

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1608446%20AND%20SRC:MED&resulttype=core&format=json

22 September 2019

issue

6378

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22 September 2019

page(s)

455-460

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The revised "Points to Consider" document

22 September 2019

cites work

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7 January 2021

Points to consider in human somatic cell therapy and gene therapy (1991)

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7 January 2021

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

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Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene

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Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits

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Murine interleukin-4 displays potent anti-tumor activity in vivo

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Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity

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Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

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Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity

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7 January 2021

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo

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7 January 2021

Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.

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7 January 2021

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

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7 January 2021

Site-specific integration by adeno-associated virus

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7 January 2021

Targeted integration of adeno-associated virus (AAV) into human chromosome 19

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7 January 2021

Retrovirus packaging cells.

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7 January 2021

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

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7 January 2021

Production of high-titer helper virus-free retroviral vectors by cocultivation of packaging cells with different host ranges.

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No retroviremia or pathology in long-term follow-up of monkeys exposed to a murine amphotropic retrovirus

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In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

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Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

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Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

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7 January 2021

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

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7 January 2021

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells

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7 January 2021

Direct gene transfer into mouse muscle in vivo

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7 January 2021

Direct gene transfer into nonhuman primate myofibers in vivo

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7 January 2021

Systemic delivery of recombinant proteins by genetically modified myoblasts

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7 January 2021

Systemic delivery of human growth hormone by injection of genetically engineered myoblasts.

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7 January 2021

Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes

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7 January 2021

Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy

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7 January 2021

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

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7 January 2021

Amphotropic murine leukemia retrovirus is not an acute pathogen for primates

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7 January 2021

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability

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7 January 2021