Loss of the proapoptotic protein, Bim, breaks B cell anergy (Q36228387)

12 August 2017

Loss of the proapoptotic protein, Bim, breaks B cell anergy (English)

1 reference

12 August 2017

Philippa Marrack

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John Kappler

1 reference

12 August 2017

Paula M Oliver

1 reference

12 August 2017

Tibor Vass

series ordinal

1 reference

12 August 2017

language of work or name

English

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publication date

6 March 2006

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Journal of Experimental Medicine

12 August 2017

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12 August 2017

203

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12 August 2017

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12 August 2017

731-741

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Autoreactive B cells in the marginal zone that express dual receptors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

CD5 maintains tolerance in anergic B cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Positive versus negative signaling by lymphocyte antigen receptors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Receptor editing: an approach by autoreactive B cells to escape tolerance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Receptor editing in self-reactive bone marrow B cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Three-dimensional structure of an antibody-antigen complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

The site and stage of anti-DNA B-cell deletion.

29 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Influences on the lifespan of B cell subpopulations defined by different phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Reduced life span of anergic self-reactive B cells in a double-transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Breakdown of self-tolerance in anergic B lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival function

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

The origin of anti-nuclear antibodies in bcl-2 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118238

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

21 October 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

Induction of self-tolerance in mature peripheral B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20051407

BAFF is a survival and maturation factor for mouse B cells

21 January 2018

1 reference

12 December 2020

Crystalline monoclonal antibody Fabs complexed to hen egg white lysozyme

1 reference

12 December 2020

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1 reference

12 December 2020

Identification of the earliest B lineage stage in mouse bone marrow

1 reference

12 December 2020

Editing disease-associated autoantibodies

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20051407

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

16520387

1 reference