Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase (Q36171342)

12 August 2017

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase (English)

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12 August 2017

R Kast

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12 August 2017

H Schirok

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12 August 2017

S Figueroa-Pérez

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12 August 2017

J Mittendorf

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12 August 2017

M J Gnoth

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12 August 2017

H Apeler

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12 August 2017

J Lenz

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12 August 2017

J K Franz

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12 August 2017

A Knorr

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12 August 2017

J Hütter

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12 August 2017

M Lobell

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12 August 2017

K Zimmermann

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12 August 2017

K Münter

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12 August 2017

K H Augstein

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12 August 2017

H Ehmke

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12 August 2017

J P Stasch

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12 August 2017

language of work or name

English

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publication date

15 October 2007

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British Journal of Pharmacology

12 August 2017

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12 August 2017

152

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12 August 2017

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12 August 2017

1070-1080

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The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Development of specific Rho-kinase inhibitors and their clinical application

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Calcium sensitization as a pharmacological target in vascular smooth-muscle regulation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Zipper-interacting protein kinase induces Ca(2+)-free smooth muscle contraction via myosin light chain phosphorylation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Regulation and functions of Rho-associated kinase

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

H-series protein kinase inhibitors and potential clinical applications

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

In hypertension, the kidney is not always the heart of the matter

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Design and synthesis of Rho kinase inhibitors (I).

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2095102

Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities

23 September 2018

1 reference

12 December 2020

Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors

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12 December 2020

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1 reference

12 December 2020

Long-term blockade of the angiotensin II receptor in renin transgenic rats, salt-loaded Dahl rats, and stroke-prone spontaneously hypertensive rats

1 reference

12 December 2020

Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage

1 reference

12 December 2020

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0707484

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release_qfaxwruzc5acdakzx2chh7rzwa

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qfaxwruzc5acdakzx2chh7rzwa

24 November 2022

mapped directly with Wikidata item

1 reference

12 August 2017

PubMed publication ID

17934515

1 reference