Progress in Spinobulbar muscular atrophy research: insights into neuronal dysfunction caused by the polyglutamine-expanded androgen receptor. (Q36129336)

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English	Progress in Spinobulbar muscular atrophy research: insights into neuronal dysfunction caused by the polyglutamine-expanded androgen receptor.	scientific article

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11 January 2020

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Progress in Spinobulbar muscular atrophy research: insights into neuronal dysfunction caused by the polyglutamine-expanded androgen receptor (English)

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11 January 2020

muscular atrophy

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Lenore K Beitel

1

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11 January 2020

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T Scanlon

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11 January 2020

B Gottlieb

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11 January 2020

M A Trifiro

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11 January 2020

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1 January 2005

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11 January 2020

Neurotoxicity Research

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11 January 2020

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11 January 2020

3

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11 January 2020

219-230

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11 January 2020

Nuclear receptors and disease: androgen receptor

1 reference

https://api.crossref.org/works/10.1007%2FBF03036451

21 January 2018

Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1007%2FBF03036451

21 January 2018

Spinobulbar muscular atrophy can mimic ALS: The importance of genetic testing in male patients with atypical ALS

1 reference

https://api.crossref.org/works/10.1007%2FBF03036451

21 January 2018

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

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https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Androgen receptors containing expanded polyglutamine tracts exhibit progressive toxicity when stably expressed in the neuroblastoma cell line, SH-SY 5Y.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference

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https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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inferred from PubMed ID database lookup

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Evidence for a repressive function of the long polyglutamine tract in the human androgen receptor: possible pathogenetic relevance for the (CAG)n-expanded neuronopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamine repeats and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Implications of a polyglutamine tract in the function of the human androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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CREB-binding protein sequestration by expanded polyglutamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Polyglutamine protein aggregation and toxicity are linked to the cellular stress response

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked bulbospinal neuronopathy: Kennedy disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

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Phenotypic manifestations associated with CAG-repeat expansion in the androgen receptor gene in male patients and heterozygous females: a clinical and molecular study of 30 families

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kennedy's disease: pathogenesis and clinical approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Pathogenesis of polyglutamine disorders: aggregation revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Characterization of intracellular aggregates using fluorescently-tagged polyglutamine-expanded androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of polyglutamine expansion in the human androgen receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of the size of the Golgi apparatus of spinal anterior horn cells in patients with X‐linked spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kennedy's disease. Phosphorylation of the polyglutamine-expanded form of androgen receptor regulates its cleavage by caspase-3 and enhances cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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A mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of proteolysis in polyglutamine disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

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A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary sensory neurons in X-linked recessive bulbospinal neuropathy: histopathology and androgen receptor gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors reduce polyglutamine toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyotrophic Lateral Sclerosis Mimic Syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15897156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF03036451

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15897156%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15897156%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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