A new wrinkle on pain relief: re-engineering clostridial neurotoxins for analgesics (Q36101373)

12 August 2017

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title

A new wrinkle on pain relief: re-engineering clostridial neurotoxins for analgesics (English)

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12 August 2017

Keith A Foster

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12 August 2017

publication date

1 April 2005

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12 August 2017

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

563-569

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Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

12 August 2017

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Botulinum Toxin Injection into Extraocular Muscles as an Alternative to Strabismus Surgery

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Botox: beyond wrinkles

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New therapeutic indications for botulinum toxins

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Botulinum toxin therapy in pain management

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Botulinum toxins in pain management

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The use of botulinum toxins for chronic pain and headaches

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A focused review on the use of botulinum toxins for neuropathic pain

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7 January 2021

Possible mechanisms for the effects of botulinum toxin on pain

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7 January 2021

Neurobiological basis for the use of botulinum toxin in pain therapy

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7 January 2021

Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms

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7 January 2021

Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins

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7 January 2021

Presynaptic effects of botulinum toxin type A on the neuronally evoked response of albino and pigmented rabbit iris sphincter and dilator muscles

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7 January 2021

Pharmacology and immunology of botulinum toxin serotypes

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7 January 2021

Botulinum toxin therapy for pain and inflammatory disorders: mechanisms and therapeutic effects

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7 January 2021

Evidence for antinociceptive activity of botulinum toxin type A in pain management

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7 January 2021

Subcutaneous administration of botulinum toxin A reduces formalin-induced pain

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7 January 2021

Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity

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7 January 2021

Molecular pharmacology of botulinum toxin and tetanus toxin

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7 January 2021

Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity

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7 January 2021

A 50-kDa fragment from the NH2-terminus of the heavy subunit of Clostridium botulinum type A neurotoxin forms channels in lipid vesicles

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7 January 2021

Crystal structure of botulinum neurotoxin type A and implications for toxicity

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7 January 2021

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

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7 January 2021

Comparison of the pH-induced conformational change of different clostridial neurotoxins.

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7 January 2021

Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons.

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7 January 2021

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

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7 January 2021

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

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7 January 2021

Presynaptic receptor arrays for clostridial neurotoxins.

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7 January 2021

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.

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7 January 2021

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A

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7 January 2021

A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitro

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7 January 2021

SNAP receptors implicated in vesicle targeting and fusion

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7 January 2021

Histochemical localization of galactose-containing glycoconjugates in sensory neurons and their processes in the central and peripheral nervous system of the rat.

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7 January 2021

Evidence for glycoconjugate in nociceptive primary sensory neurons and its origin from the Golgi complex

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7 January 2021

Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.

1 reference

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7 January 2021

Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain

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7 January 2021

Persistence of botulinum neurotoxin action in cultured spinal cord cells

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7 January 2021

The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A.

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7 January 2021

Plasma membrane localization signals in the light chain of botulinum neurotoxin

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7 January 2021

Synaptic transmission: inhibition of neurotransmitter release by botulinum toxins

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7 January 2021

10.1016/S1359-6446(05)03389-1

Identifiers

DOI

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12 August 2017

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