Transcription factor ISL1 is essential for pacemaker development and function. (Q36040426)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26193633%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Transcription factor ISL1 is essential for pacemaker development and function (English)

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19 February 2020

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19 February 2020

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19 February 2020

Christopher K Glass

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19 February 2020

Qingquan Zhang

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19 February 2020

Shaowei Zhuang

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19 February 2020

Xiaohui Gong

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19 February 2020

Nathanael J Spann

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19 February 2020

Cizhong Jiang

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19 February 2020

Xinkai Cao

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19 February 2020

Xiaodong Zhao

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19 February 2020

Xiaoli Zhang

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19 February 2020

Lei Bu

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19 February 2020

Gang Wang

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19 February 2020

H S Vincent Chen

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19 February 2020

Tao Zhuang

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19 February 2020

Jie Yan

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19 February 2020

Peng Geng

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19 February 2020

Lina Luo

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19 February 2020

Indroneal Banerjee

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19 February 2020

Yihan Chen

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19 February 2020

Alexander C Zambon

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19 February 2020

Ju Chen

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19 February 2020

Yunfu Sun

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19 February 2020

Sylvia M Evans

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19 February 2020

language of work or name

English

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publication date

20 July 2015

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Journal of Clinical Investigation

19 February 2020

published in

1 reference

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19 February 2020

volume

125

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19 February 2020

issue

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19 February 2020

page(s)

3256-3268

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RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells

19 February 2020

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A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.

2 October 2017

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Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function

2 October 2017

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HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice

2 October 2017

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2 October 2017

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Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

2 October 2017

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New insights into pacemaker activity: promoting understanding of sick sinus syndrome

2 October 2017

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Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development

2 October 2017

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2 October 2017

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The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.

2 October 2017

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Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification

2 October 2017

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Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene

2 October 2017

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Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel

2 October 2017

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Stem cells as biological heart pacemakers

2 October 2017

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Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes

2 October 2017

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PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes

2 October 2017

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The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

2 October 2017

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Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

2 October 2017

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Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

2 October 2017

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The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

2 October 2017

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Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development

2 October 2017

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Pacemaker channel dysfunction in a patient with sinus node disease

2 October 2017

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Neuregulin-1 promotes formation of the murine cardiac conduction system

2 October 2017

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2 October 2017

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2 October 2017

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A family of hyperpolarization-activated mammalian cation channels

2 October 2017

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2 October 2017

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2 October 2017

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Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

2 October 2017

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The sinus venosus progenitors separate and diversify from the first and second heart fields early in development

2 October 2017

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Tamoxifen-inducible gene deletion in the cardiac conduction system

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Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells

11 July 2018

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Phosphorylation and regulation of the Ca(2+)-pumping ATPase in cardiac sarcoplasmic reticulum by calcium/calmodulin-dependent protein kinase

11 July 2018

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Optical Monitoring of Spontaneous Electrical Activity of 8-somite Embryonic Chick Heart

11 July 2018

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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

11 July 2018

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T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

23 September 2018

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Molecular analysis of patterning of conduction tissues in the developing human heart.

23 September 2018

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Role of HCN4 channel in preventing ventricular arrhythmia

23 September 2018

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Mesenchymal stem cells as a gene delivery system to create biological pacemaker cells in vitro

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Notch1b and neuregulin are required for specification of central cardiac conduction tissue.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Sarcoplasmic reticulum Ca(2+)-ATPase overexpression by adenovirus mediated gene transfer and in transgenic mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Localization of pacemaking activity in early embryonic heart monitored using voltage-sensitive dye.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

New recessive syndrome of microcephaly, cerebellar hypoplasia, and congenital heart conduction defect

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563735

Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene

21 October 2018

1 reference

12 December 2020

Endothelin-1 and Neuregulin-1 convert embryonic cardiomyocytes into cells of the conduction system in the mouse

1 reference

12 December 2020

Direct Nkx2-5 Transcriptional Repression of Isl1 Controls Cardiomyocyte Subtype Identity

1 reference

12 December 2020

Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization

1 reference

12 December 2020

Ventricular pacing or dual-chamber pacing for sinus-node dysfunction

1 reference

12 December 2020

Location of pacemaker in chick embryo heart at the time of initiation of heartbeat

1 reference

12 December 2020

The development of the conduction system in the mouse embryo heart

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI68257

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26193633%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26193633%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

26193633

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26193633%20AND%20SRC:MED&resulttype=core&format=json