MPP+: mechanism for its toxicity in cerebellar granule cells (Q36012067)

11 August 2017

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title

MPP+: mechanism for its toxicity in cerebellar granule cells (English)

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11 August 2017

Rosa A González-Polo

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11 August 2017

Germán Soler

series ordinal

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11 August 2017

José M Fuentes

series ordinal

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11 August 2017

publication date

1 December 2004

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11 August 2017

published in

Molecular Neurobiology

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11 August 2017

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11 August 2017

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11 August 2017

page(s)

253-264

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The parkinsonian toxin MPTP: action and mechanism.

11 August 2017

cites work

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Regional localization of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) uptake: Mismatch between its uptake and neurotoxic sites

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Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators

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Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons

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12 December 2020

Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells.

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12 December 2020

1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3.

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12 December 2020

Organelle-specific initiation of cell death pathways

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Implication of dopamine transporter system on 1-methyl-4-phenylpyridinium and rotenone effect in striatal synaptosomes.

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12 December 2020

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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12 December 2020

Mitochondria as the central control point of apoptosis

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12 December 2020

Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants

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12 December 2020

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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12 December 2020

Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat

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12 December 2020

Neuroprotective effect of the iron chelator desferrioxamine against MPP+ toxicity on striatal dopaminergic terminals

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12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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12 December 2020

Cell death induced by MPTP, a substrate for monoamine oxidase B.

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12 December 2020

Selective release of glutamate from cerebellar granule cells differentiating in culture.

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12 December 2020

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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12 December 2020

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12 December 2020

Production of Reactive Oxygen Species and Release of l‐Glutamate During Superoxide Anion‐Induced Cell Death of Cerebellar Granule Neurons

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Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Prevention of the nigrostriatal toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by inhibitors of 3,4-dihydroxyphenylethylamine transport

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12 December 2020

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro

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12 December 2020

Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease

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12 December 2020

1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms

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Recent advances on neuronal caspases in development and neurodegeneration

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases

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12 December 2020

1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide

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12 December 2020

Vitamin E blocks early events induced by 1-methyl-4-phenylpyridinium (MPP+) in cerebellar granule cells.

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12 December 2020

Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP+) in ventral mesencephalic-striatal co-culture in rat.

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12 December 2020

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

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12 December 2020

Survival, morphology and adhesion properties of cerebellar interneurones cultured in chemically defined and serum-supplemented medium

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12 December 2020

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

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12 December 2020

Metabolic effects of 1-methyl-4-phenylpyridinium (MPP(+)) in primary neuron cultures.

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12 December 2020

Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism.

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12 December 2020

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

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12 December 2020

Cytokines regulate L-arginine-dependent cyclic GMP production in rat glial cells.

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12 December 2020

Mechanisms of cell toxicity.

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12 December 2020

Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

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12 December 2020

Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion

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12 December 2020

Comparative studies on the mechanisms of paraquat and 1-methyl-4-phenylpyridine (MPP+) cytotoxicity

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12 December 2020

Contribution of apoptotic cell death to renal injury.

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12 December 2020

MPP(+) causes inhibition of cellular energy supply in cerebellar granule cells

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12 December 2020

Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds

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12 December 2020

Effect of 1-methyl-4-phenylpyridinium (MPP+) on mitochondrial membrane potential in cerebellar neurons: interaction with the NMDA receptor.

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12 December 2020

1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism.

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12 December 2020

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons

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12 December 2020

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

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12 December 2020

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

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12 December 2020

Carrier-independent entry of 1-methyl-4-phenylpyridinium (MPP+) into adrenal chromaffin cells as a consequence of charge delocalization

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12 December 2020

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

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12 December 2020

Iron, melanin and dopamine interaction: relevance to Parkinson's disease

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12 December 2020

1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.

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12 December 2020

Glucose protection from MPP+-induced apoptosis depends on mitochondrial membrane potential and ATP synthase

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12 December 2020

Mechanisms of MPP(+) incorporation into cerebellar granule cells

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12 December 2020

Cell death during development

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12 December 2020

Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes

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12 December 2020

Glutamate neurotoxicity in rat cerebellar granule cells: a major role for xanthine oxidase in oxygen radical formation

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12 December 2020

The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.

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12 December 2020

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

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12 December 2020

Developmental cell death: morphological diversity and multiple mechanisms

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12 December 2020

Reactive oxygen species induce different cell death mechanisms in cultured neurons

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12 December 2020

Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

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12 December 2020

Involvement of free radicals in MPP+ neurotoxicity against rat dopaminergic neurons in culture

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12 December 2020

Tantalizing Thanatos: unexpected links in death pathways

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12 December 2020

Apoptosis induction by a dopaminergic neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP(+)), and inhibition by epidermal growth factor in GH3 cells

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12 December 2020

The effects of 1-methyl-4-phenylpyridinium ion (MPP+) on the efflux and metabolism of endogenous dopamine in rat striatal slices

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12 December 2020

Identifiers

DOI

10.1385/MN:30:3:253

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Dimensions Publication ID

11 August 2017

1018162130

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